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View Structure Prediction Details

Protein: BUD2
Organism: Saccharomyces cerevisiae
Length: 1104 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BUD2.

Description E-value Query
Range		 Subject
Range
gi|395289 - gi|395289|emb|CAA52228.1| CLA2 [Saccharomyces cerevisiae]
 0.0 [1..1104] [1..1104]
gi|6635197 - gi|6635197|dbj|BAA25464.2| KIAA0538 protein [Homo sapiens]
 0.0 [181..844] [2..640]
RASA3_MOUSE, RSG... - (Q60790) Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII), Ras GTPase...
 0.0 [209..852] [14..645]
RASA3_BOVIN - Ras GTPase-activating protein 3 OS=Bos taurus GN=RASA3 PE=2 SV=1
 0.0 [211..852] [16..645]

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Predicted Domain #1
Region A:
Residues: [1-194] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNNEPAQS RTSYFKLNEF LSNVKHYKNT FKGEIQWCNN LSLNDWKTHY LQITSTGALT  60
   61 HSIDELTADS TNIQPIIKHL QQCRIEIIKD KHSSFKDINA NCNFIIQVNT SGKDNKVYLR 120
  121 VKSWSDFKKL LTCLIWWSSM KTNGIFNKFQ VSRPLEFKSK KMAKPESLLV YKLNVFGPIV 180
  181 KNIVLPPATN ILES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [195-316] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDIINNDDNS VGWFSAMGVL KSNGMLDLLL QSDGSLIYSL NISQLLRSEI RILDSSVLQS  60
   61 ENSLFLGELP LLRSQLGLEK FRIENIASAA TNSSDISQEI IVEFPLRIDL EDCFIALQSF 120
  121 AR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.522879
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [317-466] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEYLSITGSD KSNDMKISNS FKISILEANF QSINLNDKNN TPWSIFTDIT AWGHTWARTS  60
   61 MVSNSSNPFW REEFQFNELL RLTNSYLEIK QLFHDLNNKK RLRLIGKIKI TQEIINDTRY 120
  121 NKETRLPIMD VDNKNFQIGT ICIKISSNLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.522879
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 5.23789256375467 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 5.21562004568462 bayes_pls_golite062009
small GTPase regulator activity 4.91645234075732 bayes_pls_golite062009
GTPase activator activity 4.81440293338491 bayes_pls_golite062009
Ras GTPase activator activity 4.76400460221691 bayes_pls_golite062009
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
enzyme regulator activity 4.5322075775333 bayes_pls_golite062009
enzyme activator activity 4.29367232260052 bayes_pls_golite062009
Rac GTPase activator activity 3.29568423512865 bayes_pls_golite062009
binding 1.62780792681766 bayes_pls_golite062009
protein binding 1.21496582666968 bayes_pls_golite062009
GTPase binding 0.240141218420366 bayes_pls_golite062009
small GTPase binding 0.0713778754122761 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [467-535] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FILPSTNFVK LEKLLMNANL SMVSNLIYKS SSSMENDNKL TQTSIIFLDI FQSLSRIEEW  60
   61 FHVLIDKEL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [759-827] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFNSKILNLS STISRPKLAI EQTMLDDLPQ IPYLLDKNLR ETEFVNLIVN FSQEDMTKME  60
   61 KYNHMDNGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 271.68867
Match: 1wer__
Description: p120GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [536-758] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKIDGTVSRI NQKNLDSKHV FNSLFRGNSI LTKSIEQYFF RVGNEYLSKA LSAILKEIIE  60
   61 SNKSCELDPA RVKEKDEVKK RKIIADNYKR LYSWVTKIWK RLYATSNDLP IEIRNVLKIF 120
  121 RQKLEIICID DTLQIILNGI SGLLFLRFFC PVILNPKLFK YVSQNLNETA RRNLTLISKV 180
  181 LLNLSTLTQF ANKEPWLMKM NNFIDKRHND LLDYIDKMTQ KKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 271.68867
Match: 1wer__
Description: p120GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [828-1104] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGELIEEEGL LSGSSLNLSV DKKDLDSPIE VKPEIGELEF EKITENNTEI FGDDLMNLLK  60
   61 SDDVGSRSRD LDNGANSGIK FNSIIPKAEE EKHAMKELEQ ESCLLYNRIN HIRKRLSGYE 120
  121 CASSTLFEDK KYSISLSHKI FYEEIKEGKE IVLKLLNKPT NENSSARLQK FFTKGVSSKS 180
  181 NNTVGDSYCK FLTIDVSDEN PKSSNKTSVH GTSSENGAKD DYLTLPNSQG KGNLGNRFSP 240
  241 TKLSRIMRKP PNADVPKEQN SRKLTRWFKK KKETGGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle