YRC Public Data Repository - Protein Structure Prediction

Protein:	DRS2
Organism:	Saccharomyces cerevisiae
Length:	1355 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DRS2.

Description	E-value	Query Range	Subject Range
SPBC887.12 - P-type ATPase YOOC_SCHPO - Probable phospholipid-transporting ATPase C887.12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24...	0.0	[50..1305]	[34..1258]
gi\|9624461 - gi\|9624461\|gb\|AAF90186.1\|AF280421_1 putative calcium transporting ATPase [Ajellomyces capsulatus]	0.0	[30..1313]	[25..1304]
DRS2 - Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secre... gi\|6319293\|ref\|N... - Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secre...	0.0	[1..1355]	[1..1355]
ATP8A1 - ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	0.0	[154..1298]	[5..1160]
AT8A1_MOUSE, A8A... - Probable phospholipid-transporting ATPase IA OS=Mus musculus GN=Atp8a1 PE=1 SV=1, (P70704) Potential...	0.0	[154..1298]	[5..1145]
AT8A1_BOVIN - Probable phospholipid-transporting ATPase IA OS=Bos taurus GN=ATP8A1 PE=1 SV=2	0.0	[154..1298]	[5..1145]
ALA4_ARATH - Probable phospholipid-transporting ATPase 4 OS=Arabidopsis thaliana GN=ALA4 PE=3 SV=2	0.0	[155..1264]	[7..1177]

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Predicted Domain #1

Region A:
Residues: [1-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDDRETPPK RKPGEDDTLF DIDFLDDTTS HSGSRSKVTN SHANGYYIPP SHVLPEETID  60
   61 LDADDDNIEN DVHENLFMSN NHDDQTSWNA NRFDSDAYQP QSLRAVKPPG LFARFGNGLK 120
  121 NAFTFKRKKG PESFEM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [137-205]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHYNAVTNNE LDDNYLDSRN KFNIKILFNR YILRKNVGDA EGNGEPRVIH INDSLANSSF  60
   61 GYSDNHIST

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [285-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIFSEAHDDF VEKRWIDIRV GDIIRVKSEE PIPADTIILS SSEPEGLCYI ETANLDGETN  60
   61 LKIKQSRVET AKFIDVKTLK NMNGKVVSEQ PNSSLYTYEG TMTLNDRQIP LSPDQMILRG 120
  121 ATLRNTAWIF GLVIFTGHET KLLRNATATP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1060.457575
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #3

Region A:
Residues: [206-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKYNFATFLP KFLFQEFSKY ANLFFLCTSA IQQVPHVSPT NRYTTIGTLL VVLIVSAMKE  60
   61 CIEDIKRAN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [435-517]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKRTAVEKII NRQIIRLFTV LIVLILISSI GNVIMSTADA KHLSYLYLEG TNKAGLFFKD  60
   61 FLTFWILFSN LVPISLFVTV ELI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [1004-1265]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYQRISVAIL YSFYKNTALY MTQFWYVFAN AFSGQSIMES WTMSFYNLFF TVWPPFVIGV  60
   61 FDQFVSSRLL ERYPQLYKLG QKGQFFSVYI FWGWIINGFF HSAIVFIGTI LIYRYGFALN 120
  121 MHGELADHWS WGVTVYTTSV IIVLGKAALV TNQWTKFTLI AIPGSLLFWL IFFPIYASIF 180
  181 PHANISREYY GVVKHTYGSG VFWLTLIVLP IFALVRDFLW KYYKRMYEPE TYHVIQEMQK 240
  241 YNISDSRPHV QQFQNAIRKV RQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1060.457575
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #4

Region A:
Residues: [275-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDKELNNSTA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [518-567]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYYQAFMIGS DLDLYYEKTD TPTVVRTSSL VEELGQIEYI FSDKTGTLTR

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [813-1003]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQDGVPETIH TLQEAGIKIW VLTGDRQETA INIGMSCRLL SEDMNLLIIN EETRDDTERN  60
   61 LLEKINALNE HQLSTHDMKS LALVIDGKSL GFALEPELED YLLTVAKLCK AVICCRVSPL 120
  121 QKALVVKMVK RKSSSLLLAI ASGANDVSMI QAAHVGVGIS GMEGMQAARS ADIALGQFKF 180
  181 LKKLLLVHGS W

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1060.457575
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #5

Region A:
Residues: [568-812]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIMEFKSCSI AGHCYIDKIP EDKTATVEDG IEVGYRKFDD LKKKLNDPSD EDSPIINDFL  60
   61 TLLATCHTVI PEFQSDGSIK YQAASPDEGA LVQGGADLGY KFIIRKGNSV TVLLEETGEE 120
  121 KEYQLLNICE FNSTRKRMSA IFRFPDGSIK LFCKGADTVI LERLDDEANQ YVEATMRHLE 180
  181 DYASEGLRTL CLAMRDISEG EYEEWNSIYN EAATTLDNRA EKLDEAANLI EKNLILIGAT 240
  241 AIEDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1060.457575
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #6

Region A:
Residues: [1266-1355]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQRMKKQRGF AFSQAEEGGQ EKIVRMYDTT QKRGKYGELQ DASANPFNDN NGLGSNDFES  60
   61 AEPFIENPFA DGNQNSNRFS SSRDDISFDI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits