YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SEC14

General Information:
Name(s) found: SEC14 / YMR079W [SGD]
Description(s) found:
Found 31 descriptions.
SHOW ALL
  • Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    Biological Process: ascospore formation [IGILink to PubMed article][IMPLink to PubMed article]
    phosphatidylcholine metabolic process [IDALink to PubMed article][TASLink to PubMed article]
    Golgi to plasma membrane transport [IMPLink to PubMed article]
    phospholipid transport [IDALink to PubMed article]
    phosphatidylinositol metabolic process [TASLink to PubMed article]
    Molecular Function: phosphatidylinositol transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTQQEKEFL ESYPQNCPPD ALPGTPGNLD SAQEKALAEL RKLLEDAGFI ERLDDSTLLR  60
   61 FLRARKFDVQ LAKEMFENCE KWRKDYGTDT ILQDFHYDEK PLIAKFYPQY YHKTDKDGRP 120
  121 VYFEELGAVN LHEMNKVTSE ERMLKNLVWE YESVVQYRLP ACSRAAGHLV ETSCTIMDLK 180
  181 GISISSAYSV MSYVREASYI SQNYYPERMG KFYIINAPFG FSTAFRLFKP FLDPVTVSKI 240
  241 FILGSSYQKE LLKQIPAENL PVKFGGKSEV DESKGGLYLS DIGPWRDPKY IGPEGEAPEA 300
  301 FSMK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PTC7 SEC14
    View Details Krogan NJ, et al. (2006) BSP1 PTC7 SEC14 YKL091C
    View Details Qiu et al. (2008) CDC50 DNF3 DRS2 SEC14 SFH5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEC14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..19]
    [81..304]    		 PSI-BLAST 1794.69897 N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
    2 View Details [20..80] PSI-BLAST 1794.69897 N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phospholipid transporter activity
    		•  4.82372291869245 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.98714900064429 bayes_pls_golite062009
  • phosphatidylinositol transporter activity
    		•  3.08477039249457 bayes_pls_golite062009
  • transporter activity
    		•  2.25865143268098 bayes_pls_golite062009
  • binding
    		•  2.07034659478808 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.84980732779905 bayes_pls_golite062009
  • retinoid binding
    		•  1.4508809653482 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.32450443851017 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.14391953556505 bayes_pls_golite062009
  • vitamin binding
    		•  0.87942237566918 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.418179505285201 bayes_pls_golite062009
  • protein binding
    		•  0.408110742195811 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.265815679858875 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0570899657188049 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle