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View Structure Prediction Details

Protein: SEC14
Organism: Saccharomyces cerevisiae
Length: 304 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC14.

Description E-value Query
Range		 Subject
Range
gi|190408310 - gi|190408310|gb|EDV11575.1| phosphatidylcholine transfer protein [Saccharomyces cerevisiae RM11-1a]
SEC14_YEAST - SEC14 cytosolic factor OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC14 PE=1 SV=3
SEC14 - Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, an...
gi|151946237 - gi|151946237|gb|EDN64468.1| phosphatidylcholine transporter [Saccharomyces cerevisiae YJM789]
 7.0E-88 [1..304] [1..304]
SEC14_CANGA - SEC14 cytosolic factor OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL...
SEC14_CANGA, SC1... - SEC14 cytosolic factor OS=Candida glabrata GN=SEC14 PE=3 SV=1, (P53989) SEC14 cytosolic factor (Phos...
 2.0E-84 [1..304] [1..302]
SEC14_KLULA - SEC14 cytosolic factor OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 ...
SEC14_KLULA, SC1... - SEC14 cytosolic factor OS=Kluyveromyces lactis GN=SEC14 PE=3 SV=2, (P24859) SEC14 cytosolic factor (...
 2.0E-83 [1..303] [1..301]
SFH3_ARATH - Phosphatidylinositol/phosphatidylcholine transfer protein SFH3 OS=Arabidopsis thaliana GN=SFH3 PE=2 ...
 4.0E-80 [27..299] [63..341]
gi|14517816 - gi|14517816|gb|AAK64378.1|AF366901_1 phosphatidylinositol transfer-like protein II [Lotus japonicus]
 2.0E-79 [8..299] [29..327]
SEC14_CANAL - SEC14 cytosolic factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SEC14 PE=2 SV=1
SEC14_CANAL, SC1... - SEC14 cytosolic factor OS=Candida albicans GN=SEC14 PE=2 SV=1, (P46250) SEC14 cytosolic factor (Phos...
gi|238882460 - gi|238882460|gb|EEQ46098.1| SEC14 cytosolic factor [Candida albicans WO-1]
 3.0E-79 [1..303] [1..301]
SEC14_YARLI, SC1... - SEC14 cytosolic factor OS=Yarrowia lipolytica GN=SEC14 PE=3 SV=2, (P45816) SEC14 cytosolic factor (P...
SEC14_YARLI - SEC14 cytosolic factor OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SEC14 PE=3 SV=2
 1.0E-78 [2..298] [1..294]

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Predicted Domain #1
Region A:
Residues: [1-19] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTQQEKEFL ESYPQNCPP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [81-304] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWRKDYGTDT ILQDFHYDEK PLIAKFYPQY YHKTDKDGRP VYFEELGAVN LHEMNKVTSE  60
   61 ERMLKNLVWE YESVVQYRLP ACSRAAGHLV ETSCTIMDLK GISISSAYSV MSYVREASYI 120
  121 SQNYYPERMG KFYIINAPFG FSTAFRLFKP FLDPVTVSKI FILGSSYQKE LLKQIPAENL 180
  181 PVKFGGKSEV DESKGGLYLS DIGPWRDPKY IGPEGEAPEA FSMK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1794.69897
Match: 1aua__
Description: N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phospholipid transporter activity 4.82372291869245 bayes_pls_golite062009
lipid transporter activity 3.98714900064429 bayes_pls_golite062009
phosphatidylinositol transporter activity 3.08477039249457 bayes_pls_golite062009
transporter activity 2.25865143268098 bayes_pls_golite062009
binding 2.07034659478808 bayes_pls_golite062009
substrate-specific transporter activity 1.84980732779905 bayes_pls_golite062009
retinoid binding 1.4508809653482 bayes_pls_golite062009
isoprenoid binding 1.32450443851017 bayes_pls_golite062009
transmembrane transporter activity 1.14391953556505 bayes_pls_golite062009
vitamin binding 0.87942237566918 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.418179505285201 bayes_pls_golite062009
protein binding 0.408110742195811 bayes_pls_golite062009
transcription regulator activity 0.265815679858875 bayes_pls_golite062009
protein transporter activity 0.0570899657188049 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [20-80] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DALPGTPGNL DSAQEKALAE LRKLLEDAGF IERLDDSTLL RFLRARKFDV QLAKEMFENC  60
   61 E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1794.69897
Match: 1aua__
Description: N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle