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Protein Overview: MUS81

General Information:
Name(s) found: MUS81 / YDR386W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 632 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IMPLink to PubMed article][IPILink to PubMed article]
    Holliday junction resolvase complex [IDALink to PubMed article]
    Biological Process: DNA repair [IGILink to PubMed article]
    reciprocal meiotic recombination [IGILink to PubMed article]
    DNA topological change [IGILink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    Molecular Function: endonuclease activity [IDALink to PubMed article]
    crossover junction endodeoxyribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSSNLKDL YIEWLQELVD GLTPKQEQLK IAYEKAKRNL QNAEGSFYYP TDLKKVKGIG  60
   61 NTIIKRLDTK LRNYCKIHHI SPVEAPSLTQ TSSTRPPKRT TTALRSIVNS CENDKNEAPE 120
  121 EKGTKKRKTR KYIPKKRSGG YAILLSLLEL NAIPRGVSKE QIIEVAGKYS DHCMTPNFST 180
  181 KEFYGAWSSI AALKKHSLVL EEGRPKRYSL TEEGVELTKS LKTADGISFP KENEEPNEYS 240
  241 VTRNESSEFT ANLTDLRGEY GKEEEPCDIN NTSFMLDITF QDLSTPQRLQ NNVFKNDRLN 300
  301 SQTNISSHKL EEVSDDQTVP DSALKAKSTI KRRRYNGVSY ELWCSGDFEV FPIIDHREIK 360
  361 SQSDREFFSR AFERKGMKSE IRQLALGDII WVAKNKNTGL QCVLNTIVER KRLDDLALSI 420
  421 RDNRFMEQKN RLEKSGCEHK YYLIEETMSG NIGNMNEALK TALWVILVYY KFSMIRTCNS 480
  481 DETVEKIHAL HTVISHHYSQ KDLIVIFPSD LKSKDDYKKV LLQFRREFER KGGIECCHNL 540
  541 ECFQELMGKG DLKTVGELTI HVLMLVKGIS LEKAVAIQEI FPTLNKILMA YKTCSSEEEA 600
  601 KLLMFNVLGD APGAKKITKS LSEKIYDAFG KL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MMS4 MUS81
    View Details Krogan NJ, et al. (2006) MMS4 MUS81
    View Details Ho Y, et al. (2002) ADH2 CDC16 CDC33 CDC5 ERB1 FPR3 HHF1, HHF2 HHO1 ICP55 KRE33 KRI1 LOC1 MES1 MGM101 MKT1 MMS4 MUS81 NHP2 NOP12 NOP2 NUG1 PWP1 RAD53 RPC10 RPF2 SEC23 TAF14 TMA29 UBI4 UTP22 YHB1 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen STE50 MUS81 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] MSA 2.007945 View MSA. No confident structure predictions are available.
    2 View Details [227..334] deduced N/A No confident structure predictions are available.
    3 View Details [335..454] Pfam 50.086186 ERCC4 domain No confident structure predictions are available.
    4 View Details [455..632] MSA 3.038979 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  3.46780352518677 bayes_pls_golite062009
  • DNA polymerase activity
    		•  3.42429084792579 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.8990253905448 bayes_pls_golite062009
  • catalytic activity
    		•  0.585392957294978 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • four-way junction helicase activity
    		•  10.562254984301 bayes_pls_golite062009
  • DNA helicase activity
    		•  7.81641089090703 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.88121538069074 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  3.87045877570028 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.62965779224499 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  3.48615352002265 bayes_pls_golite062009
  • DNA binding
    		•  2.97855002479178 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.83758378400856 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.79236389919005 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.79104877030658 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.3008149920351 bayes_pls_golite062009
  • helicase activity
    		•  2.29491252701513 bayes_pls_golite062009
  • binding
    		•  2.17324322139334 bayes_pls_golite062009
  • nuclease activity
    		•  1.92659045080864 bayes_pls_golite062009
  • endonuclease activity
    		•  1.7109181764667 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  1.5117854648336 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.02983374615445 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.02325715570644 bayes_pls_golite062009
  • catalytic activity
    		•  0.816447099398022 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.73359455482295 bayes_pls_golite062009
  • protein binding
    		•  0.71091195096997 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle