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Protein Overview: ICP55

General Information:
Name(s) found: ICP55 / YER078C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [NASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: proteolysis [NASLink to PubMed article]
    Molecular Function: X-Pro aminopeptidase activity [ISSLink to PubMed article]
    metalloendopeptidase activity [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHRINPVRF SMQSCQRYFS KLVSPLEQHK SNTFTNRVRI PIEAGQPLHE TRPFLIKSGE  60
   61 LTPGISALEY YERRIRLAET LPPKSCVILA GNDIQFASGA VFYPFQQEND LFYLSGWNEP 120
  121 NSVMILEKPT DSLSDTIFHM LVPPKDAFAE KWEGFRSGVY GVQEIFNADE SASINDLSKY 180
  181 LPKIINRNDF IYFDMLSTSN PSSSNFKHIK SLLDGSGNSN RSLNSIANKT IKPISKRIAE 240
  241 FRKIKSPQEL RIMRRAGQIS GRSFNQAFAK RFRNERTLDS FLHYKFISGG CDKDAYIPVV 300
  301 ATGSNSLCIH YTRNDDVMFD DEMVLVDAAG SLGGYCADIS RTWPNSGKFT DAQRDLYEAV 360
  361 LNVQRDCIKL CKASNNYSLH DIHEKSITLM KQELKNLGID KVSGWNVEKL YPHYIGHNLG 420
  421 LDVHDVPKVS RYEPLKVGQV ITIEPGLYIP NEESFPSYFR NVGIRIEDDI AIGEDTYTNL 480
  481 TVEAVKEIDD LENVMQNGLS TKFEEDQVAP L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADK1 ICP55
    View Details Ho Y, et al. (2002) ARP2 CDC5 HHF1, HHF2 HHO1 ICP55 LOC1 MGM101 MUS81 NOP12 NUG1 RFA1 RPT2 RVB1 TAF14 TMA29 YRA1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ICP55 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..240] PSI-BLAST 663.9794 Aminopeptidase P; Aminopeptidase P, C-terminal domain
    2 View Details [241..511] PSI-BLAST 663.9794 Aminopeptidase P; Aminopeptidase P, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  2.60615909541559 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.18503136472662 bayes_pls_golite062009
  • metallopeptidase activity
    		•  1.75829852010848 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43646476372001 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.89399203910285 bayes_pls_golite062009
  • binding
    		•  0.762408229471586 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.762255574851485 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.352607952828331 bayes_pls_golite062009
  • catalytic activity
    		•  0.148551873544128 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0346092896934742 bayes_pls_golite062009
  • DNA binding
    		•  0.0315289262145955 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle