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Protein Overview: MMS4

General Information:
Name(s) found: MMS4 / YBR098W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 691 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Holliday junction resolvase complex [IDALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    reciprocal meiotic recombination [IGILink to PubMed article]
    DNA topological change [IGILink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    Molecular Function: transcription coactivator activity [IDALink to PubMed article]
    endonuclease activity [IDALink to PubMed article]
    crossover junction endodeoxyribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQIVDFVED KDSRNDASIQ IIDGPSNVEI IALSESMDQD ECKRAHVSSA EMIPSSPQRK  60
   61 SVSNDVENVD LNKSIELSAP FFQDISISKL DDFSTTVNSI IDSSLRNENN AKGNAKKLLD 120
  121 DLISDEWSAD LESSGKKHNK SQYNLRDIAE KWGVQSLKNP EPIAVDCEYK TQGIGKTNSD 180
  181 ISDSPKSQIG AADILFDFPL SPVKHENPTE EKHNSIANEN SSPDNSLKPA GKQNHGEDGT 240
  241 SMAKRVYNKG EDEQEHLPKG KKRTIALSRT LINSTKLPDT VELNLSKFLD SSDSITTDVL 300
  301 STPAKGSNIV RTGSQPIFSN ANCFQEAKRS KTLTAEDPKC TKNTAREVSQ LENYIAYGQY 360
  361 YTREDSKNKI RHLLKENKNA FKRVNQIYRD NIKARSQMII EFSPSLLQLF KKGDSDLQQQ 420
  421 LAPAVVQSSY NDSMPLLRFL RKCDSIYDFS NDFYYPCDPK IVEENVLILY YDAQEFFEQY 480
  481 TSQKKELYRK IRFFSKNGKH VILILSDINK LKRAIFQLEN EKYKARVEQR LSGTEEALRP 540
  541 RSKKSSQVGK LGIKKFDLEQ RLRFIDREWH VKIHTVNSHM EFINSLPNLV SLIGKQRMDP 600
  601 AIRYMKYAHL NVKSAQDSTE TLKKTFHQIG RMPEMKANNV VSLYPSFQSL LEDIEKGRLQ 660
  661 SDNEGKYLMT EAVEKRLYKL FTCTDPNDTI E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MMS4 MUS81
    View Details Krogan NJ, et al. (2006) MMS4 MUS81
    View Details Ho Y, et al. (2002) ADH2 CDC16 CDC33 ERB1 FPR3 HHF1, HHF2 KRE33 KRI1 LOC1 MES1 MKT1 MMS4 MUS81 NHP2 NOP12 NOP2 PWP1 RAD53 RPC10 RPF2 SEC23 TAF14 UBI4 UTP22 YHB1 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NAS2 MMS4 2 Unpublished Fields Lab Data
    View Screen SLA1 MMS4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MMS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..394] FFAS03 1.28 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    2 View Details [395..456] deduced N/A No confident structure predictions are available.
    3 View Details [457..691] FFAS03 1.6 XPF from Aeropyrum pernix, complex with DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • four-way junction helicase activity
    		•  9.97778352333441 bayes_pls_golite062009
  • DNA helicase activity
    		•  7.39534793109438 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.3215200974849 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  3.18118446093396 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.15144163151183 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  2.93145997831744 bayes_pls_golite062009
  • DNA binding
    		•  2.86703202962507 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.70608150305499 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.54099670773663 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.43123013915603 bayes_pls_golite062009
  • binding
    		•  2.15665005558542 bayes_pls_golite062009
  • helicase activity
    		•  1.95147423101621 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.93355995630071 bayes_pls_golite062009
  • nuclease activity
    		•  1.53464565125134 bayes_pls_golite062009
  • endonuclease activity
    		•  1.2384221353329 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.868370062080145 bayes_pls_golite062009
  • catalytic activity
    		•  0.776505703815067 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.757551245363434 bayes_pls_golite062009
  • protein binding
    		•  0.687937183662529 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.593379763919056 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.591712648797139 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle