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Protein Overview: NAS2

General Information:
Name(s) found: NAS2 / YIL007C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 220 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEEELSKLL ANVKIDPSLT SRISQIDSFK LSELMVLKTD IETQLEAYFS VLEQQGIGMD  60
   61 SALVTPDGYP RSDVDVLQVT MIRKNVNMLK NDLNHLLQRS HVLLNQHFDN MNVKSNQDAR 120
  121 RNNDDQAIQY TIPFAFISEV VPGSPSDKAD IKVDDKLISI GNVHAANHSK LQNIQMVVMK 180
  181 NEDRPLPVLL LREGQILKTS LTPSRNWNGR GLLGCRIQEL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) NAS2 NTR2 YCL047C
    View Details Ho Y, et al. (2002) ACO1 NAS2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NAS2 MMS4 2 Unpublished Fields Lab Data
    View Screen NAS2 SAC1 2 Unpublished Fields Lab Data
    View Screen NAS2 CCZ1 2 Unpublished Fields Lab Data
    View Screen NAS2 ESL2 2 Unpublished Fields Lab Data
    View Screen NAS2 YCL073C 2 Unpublished Fields Lab Data
    View Screen NAS2 RNP1 2 Unpublished Fields Lab Data
    View Screen NAS2 RPN4 2 Drees BL, et al. (2001)
    View Screen NAS2 RPT5 2 Unpublished Fields Lab Data
    View Screen NAS2 RPT4 2 Unpublished Fields Lab Data
    View Screen NAS2 RPH1 2 Unpublished Fields Lab Data
    View Screen NAS2 UME1 2 Unpublished Fields Lab Data
    View Screen RHO4 NAS2 2 Drees BL, et al. (2001)
    View Screen NAS2 DED81 2 Unpublished Fields Lab Data
    View Screen RHO1 NAS2 2 Drees BL, et al. (2001)
    View Screen PRE7 NAS2 2 Unpublished Fields Lab Data
    View Screen NAS2 PFS1 2 Uetz P, et al. (2000)
    View Screen NAS2 IKI1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NAS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 42.0 Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.00482245922158 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.80641317919152 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.69721977392816 bayes_pls_golite062009
  • protein binding
    		•  3.40921081688513 bayes_pls_golite062009
  • binding
    		•  3.2595117613307 bayes_pls_golite062009
  • hydrolase activity
    		•  2.69939003844937 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16834620509051 bayes_pls_golite062009
  • transcription activator activity
    		•  1.37255187012662 bayes_pls_golite062009
  • transporter activity
    		•  0.666562078558936 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.510205657363692 bayes_pls_golite062009
  • enzyme binding
    		•  0.46071739042312 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.342817187733892 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.299572882681276 bayes_pls_golite062009
  • structural molecule activity
    		•  0.153277808949873 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.141613198202921 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.0604467745298803 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0283953080227368 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0187659836234897 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle