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Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. Catalysis of the hydrolysis of peptide bonds formed between L-amino acids. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: endopeptidase activity
Acc: GO:0004175
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
Synonyms:
  • proteasome endopeptidase activity
  • proteinase
  • GO:0016809
  • endoprotease activity
Proteins in PDR annotated with:
   This term: 287 [Search]
   Term or descendants: 2491 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004175 - endopeptidase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle