YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: PTC2

General Information:
Name(s) found: PTC2 / YER089C [SGD]
Description(s) found:
Found 30 descriptions.
SHOW ALL
  • Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 464 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: DNA damage checkpoint [IGILink to PubMed article]
    inactivation of MAPK activity involved in osmosensory signaling pathway [IDALink to PubMed article][IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed articleLink to PubMed article]
    response to unfolded protein [IMPLink to PubMed article][IPILink to PubMed article]
    regulation of cyclin-dependent protein kinase activity [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IDA][IEA]
    phosphoprotein phosphatase activity [IEA]
    catalytic activity [IEA]
    metal ion binding [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS DKDHIAFYGI  60
   61 FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF INTDVKLLQD PVMKEDHSGC 120
  121 TATSILVSKS QNLLVCGNAG DSRTVLATDG NAKALSYDHK PTLASEKSRI VAADGFVEMD 180
  181 RVNGNLALSR AIGDFEFKSN PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL 240
  241 TSQDCVDLVH LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA 300
  301 QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK FTRDHEAAVA 360
  361 SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID LASLEALLGA TGGVKTDSNG 420
  421 NKVTYTLPQS ALAQLLQTMG HDPASSHPEN DSNTDHKAGR SHLQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PAA1 PTC2
    View Details Krogan NJ, et al. (2006) PAA1 PTC2 PTC3 PTC4 VPS34
    View Details Gavin AC, et al. (2006) ALD6 PTC2 SHQ1
    View Details Ho Y, et al. (2002) ASF1 CDC13 EDE1 KAP95 PTC2 RAD53 SRP1 SWI4 TBF1 UTP22 YTA7

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PTC2 PAA1 2 Uetz P, et al. (2000)
    View Screen YKL036C PTC2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PTC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 517.383689 Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
    2 View Details [377..464] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.29765002420868 bayes_pls_golite062009
  • phosphatase activity
    		•  6.84540130415879 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.63839066304808 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.76293366458633 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  5.66354576593165 bayes_pls_golite062009
  • hydrolase activity
    		•  2.5631136269171 bayes_pls_golite062009
  • binding
    		•  1.74689317666387 bayes_pls_golite062009
  • catalytic activity
    		•  1.53401212718168 bayes_pls_golite062009
  • protein binding
    		•  1.47578617076714 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle