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Protein Overview: ALD6

General Information:
Name(s) found: ALD6 / YPL061W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 500 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IMPLink to PubMed article][ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: acetate biosynthetic process [IMPLink to PubMed article]
    Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKLHFDTAE PVKITLPNGL TYEQPTGLFI NNKFMKAQDG KTYPVEDPST ENTVCEVSSA  60
   61 TTEDVEYAIE CADRAFHDTE WATQDPRERG RLLSKLADEL ESQIDLVSSI EALDNGKTLA 120
  121 LARGDVTIAI NCLRDAAAYA DKVNGRTINT GDGYMNFTTL EPIGVCGQII PWNFPIMMLA 180
  181 WKIAPALAMG NVCILKPAAV TPLNALYFAS LCKKVGIPAG VVNIVPGPGR TVGAALTNDP 240
  241 RIRKLAFTGS TEVGKSVAVD SSESNLKKIT LELGGKSAHL VFDDANIKKT LPNLVNGIFK 300
  301 NAGQICSSGS RIYVQEGIYD ELLAAFKAYL ETEIKVGNPF DKANFQGAIT NRQQFDTIMN 360
  361 YIDIGKKEGA KILTGGEKVG DKGYFIRPTV FYDVNEDMRI VKEEIFGPVV TVAKFKTLEE 420
  421 GVEMANSSEF GLGSGIETES LSTGLKVAKM LKAGTVWINT YNDFDSRVPF GGVKQSGYGR 480
  481 EMGEEVYHAY TEVKAVRIKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALD6 CCT8 CYS4 ERG11 ERR3 HSP150 SLD2 TUB2 WAR1
    View Details Gavin AC, et al. (2006) ALD6 GSH1 IDH2 NEW1 PTC2 SHQ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ALD6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273]
    [464..500]    		 PSI-BLAST 2270.0 Aldehyde reductase (dehydrogenase), ALDH
    2 View Details [274..463] PSI-BLAST 2270.0 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  4.35175408702761 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  4.2273960318884 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.99564252244797 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  2.78416888468693 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  2.70230501280821 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • acyl-CoA binding
    		•  2.26220696569489 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  1.6559690223037 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • retinoid binding
    		•  0.983782635681687 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.900374761028287 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle