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View Structure Prediction Details

Protein: ALD6
Organism: Saccharomyces cerevisiae
Length: 500 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALD6.

Description E-value Query
Range		 Subject
Range
gi|60653829, gi|... - gi|60653831|gb|AAX29608.1| aldehyde dehydrogenase 1 family member A1 [synthetic construct], gi|60653...
 0.0 [5..500] [1..496]
gi|2183299 - gi|2183299|gb|AAC51652.1| aldehyde dehydrogenase 1 [Homo sapiens]
 0.0 [5..500] [1..496]
AL1A1_CHICK - Retinal dehydrogenase 1 OS=Gallus gallus GN=ALDH1A1 PE=2 SV=1
 0.0 [1..500] [1..504]
AL1A1_SHEEP - Retinal dehydrogenase 1 OS=Ovis aries GN=ALDH1A1 PE=1 SV=2
 0.0 [5..500] [1..496]
AL1A1_MACFA - Retinal dehydrogenase 1 OS=Macaca fascicularis GN=ALDH1A1 PE=2 SV=3
 0.0 [7..500] [2..496]
AL1A1_RABIT - Retinal dehydrogenase 1 OS=Oryctolagus cuniculus GN=ALDH1A1 PE=2 SV=1
 0.0 [12..500] [2..491]
AL1A1_BOVIN - Retinal dehydrogenase 1 - Bos taurus (Bovine)
 0.0 [5..500] [1..496]
gi|4586546 - gi|4586546|dbj|BAA76412.1| aldehyde dehydrogenase class 1 [Xenopus laevis]
 0.0 [14..500] [10..497]

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Predicted Domain #1
Region A:
Residues: [1-273] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKLHFDTAE PVKITLPNGL TYEQPTGLFI NNKFMKAQDG KTYPVEDPST ENTVCEVSSA  60
   61 TTEDVEYAIE CADRAFHDTE WATQDPRERG RLLSKLADEL ESQIDLVSSI EALDNGKTLA 120
  121 LARGDVTIAI NCLRDAAAYA DKVNGRTINT GDGYMNFTTL EPIGVCGQII PWNFPIMMLA 180
  181 WKIAPALAMG NVCILKPAAV TPLNALYFAS LCKKVGIPAG VVNIVPGPGR TVGAALTNDP 240
  241 RIRKLAFTGS TEVGKSVAVD SSESNLKKIT LEL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [464-500] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDSRVPFGGV KQSGYGREMG EEVYHAYTEV KAVRIKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2270.0
Match: 1nzxA_
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.09598561374689 bayes_pls_golite062009
oxidoreductase activity 4.47226217021998 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 4.35175408702761 bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity 4.2273960318884 bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity 3.87605237828483 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity 3.64672165191647 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 3.37049090049734 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2867555127991 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.99564252244797 bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity 2.81851373615334 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity 2.78416888468693 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity 2.71501590413507 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 2.70230501280821 bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity 2.43250909158896 bayes_pls_golite062009
aminobutyraldehyde dehydrogenase activity 2.35958138496479 bayes_pls_golite062009
acyl-CoA binding 2.26220696569489 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.6559690223037 bayes_pls_golite062009
retinal dehydrogenase activity 1.42867174920845 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
retinoid binding 0.983782635681687 bayes_pls_golite062009
isoprenoid binding 0.900374761028287 bayes_pls_golite062009
protein binding 0.894945263794726 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity 0.23487570676521 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [274-463] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGKSAHLVFD DANIKKTLPN LVNGIFKNAG QICSSGSRIY VQEGIYDELL AAFKAYLETE  60
   61 IKVGNPFDKA NFQGAITNRQ QFDTIMNYID IGKKEGAKIL TGGEKVGDKG YFIRPTVFYD 120
  121 VNEDMRIVKE EIFGPVVTVA KFKTLEEGVE MANSSEFGLG SGIETESLST GLKVAKMLKA 180
  181 GTVWINTYND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2270.0
Match: 1nzxA_
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle