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Protein Overview: CIT2

General Information:
Name(s) found: CIT2 / YCR005C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 460 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glutamate biosynthetic process [TASLink to PubMed article]
    glyoxylate cycle [TASLink to PubMed article]
    citrate metabolic process [TASLink to PubMed article]
    Molecular Function: citrate (Si)-synthase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVPYLNSNR NVASYLQSNS SQEKTLKERF SEIYPIHAQD VRQFVKEHGK TKISDVLLEQ  60
   61 VYGGMRGIPG SVWEGSVLDP EDGIRFRGRT IADIQKDLPK AKGSSQPLPE ALFWLLLTGE 120
  121 VPTQAQVENL SADLMSRSEL PSHVVQLLDN LPKDLHPMAQ FSIAVTALES ESKFAKAYAQ 180
  181 GISKQDYWSY TFEDSLDLLG KLPVIAAKIY RNVFKDGKMG EVDPNADYAK NLVNLIGSKD 240
  241 EDFVDLMRLY LTIHSDHEGG NVSAHTSHLV GSALSSPYLS LASGLNGLAG PLHGRANQEV 300
  301 LEWLFALKEE VNDDYSKDTI EKYLWDTLNS GRVIPGYGHA VLRKTDPRYM AQRKFAMDHF 360
  361 PDYELFKLVS SIYEVAPGVL TEHGKTKNPW PNVDAHSGVL LQYYGLKESS FYTVLFGVSR 420
  421 AFGILAQLIT DRAIGASIER PKSYSTEKYK ELVKNIESKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CIT2 PEP3 PRO2 PTC6
    View Details Qiu et al. (2008) CIT1 CIT2 CIT3 MDH3 MLS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIT2 CIT2 2 Uetz P, et al. (2000)
    View Screen CIT2 PAA1 2 Unpublished Fields Lab Data
    View Screen CIT2 MHP1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CIT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297]
    [402..460]    		 PSI-BLAST 1760.0 Citrate synthase
    2 View Details [298..401] PSI-BLAST 1760.0 Citrate synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • citrate (Si)-synthase activity
    		•  7.90380661459876 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  7.35970609422108 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.98392594633005 bayes_pls_golite062009
  • catalytic activity
    		•  2.51855037019879 bayes_pls_golite062009
  • transferase activity
    		•  1.52308910034898 bayes_pls_golite062009
  • binding
    		•  1.15467737113069 bayes_pls_golite062009
  • protein binding
    		•  0.210158634792359 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle