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Protein Overview: MDH3

General Information:
Name(s) found: MDH3 / YDL078C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 343 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    peroxisomal matrix [TAS]
    Biological Process: fatty acid beta-oxidation [TASLink to PubMed article]
    malate metabolic process [TASLink to PubMed article]
    NADH regeneration [TASLink to PubMed article]
    glyoxylate cycle [TASLink to PubMed article]
    Molecular Function: L-malate dehydrogenase activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKVAILGAS GGVGQPLSLL LKLSPYVSEL ALYDIRAAEG IGKDLSHINT NSSCVGYDKD  60
   61 SIENTLSNAQ VVLIPAGVPR KPGLTRDDLF KMNAGIVKSL VTAVGKFAPN ARILVISNPV 120
  121 NSLVPIAVET LKKMGKFKPG NVMGVTNLDL VRAETFLVDY LMLKNPKIGQ EQDKTTMHRK 180
  181 VTVIGGHSGE TIIPIITDKS LVFQLDKQYE HFIHRVQFGG DEIVKAKQGA GSATLSMAFA 240
  241 GAKFAEEVLR SFHNEKPETE SLSAFVYLPG LKNGKKAQQL VGDNSIEYFS LPIVLRNGSV 300
  301 VSIDTSVLEK LSPREEQLVN TAVKELRKNI EKGKSFILDS SKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CPR5 MDH3 PFS1 YDR248C YHL008C YHR097C
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 TRR1 UBA1 YDL124W
    View Details Qiu et al. (2008) CIT2 DCI1 ECI1 FOX2 IDP3 MDH3 MLS1 POX1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MDH3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..343] PSI-BLAST 731.751666 Malate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle