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Protein Overview: HOM2

General Information:
Name(s) found: HOM2 / YDR158W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    methionine metabolic process [TASLink to PubMed article]
    threonine metabolic process [TASLink to PubMed article]
    homoserine biosynthetic process [TAS]
    Molecular Function: aspartate-semialdehyde dehydrogenase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGKKIAGVL GATGSVGQRF ILLLANHPHF ELKVLGASSR SAGKKYVDAV NWKQTDLLPE  60
   61 SATDIIVSEC KSEFFKECDI VFSGLDADYA GAIEKEFMEA GIAIVSNAKN YRREQDVPLI 120
  121 VPVVNPEHLD IVAQKLDTAK AQGKPRPGFI ICISNCSTAG LVAPLKPLIE KFGPIDALTT 180
  181 TTLQAISGAG FSPGVPGIDI LDNIIPYIGG EEDKMEWETK KILAPLAEDK THVKLLTPEE 240
  241 IKVSAQCNRV AVSDGHTECI SLRFKNRPAP SVEQVKTCLK EYVCDAYKLG CHSAPKQTIH 300
  301 VLEQPDRPQP RLDRNRDSGY GVSVGRIRED PLLDFKMVVL SHNTIIGAAG SGVLIAEILL 360
  361 ARNLI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAT2 ACS2 ADE3 ADE6 ADH4 ADO1 AGX1 AHA1 ALA1 APE2 ARA1 BAT1 CDC10 CDC11 CDC12 CDC3 CDC33 CLU1 CPR1 CYS3 DED81 DPS1 DUN1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 OLA1 PAB1 PDX3 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SHS1 SOD1 SSZ1 THR4 TMA29 TRR1 UBA1 VMA4 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HOM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154]
    [349..365]    		 PSI-BLAST 97.154902 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
    2 View Details [155..348] PSI-BLAST 97.154902 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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