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Protein Overview: VMA4

General Information:
Name(s) found: VMA4 / YOR332W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 233 amino acids

    Gene Ontology:
    Cellular Component: vacuolar proton-transporting V-type ATPase, V1 domain [TASLink to PubMed articleLink to PubMed article]
    fungal-type vacuole membrane [TASLink to PubMed article]
    Biological Process: vacuolar acidification [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: proton-transporting ATPase activity, rotational mechanism [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAITALTP NQVNDELNKM QAFIRKEAEE KAKEIQLKAD QEYEIEKTNI VRNETNNIDG  60
   61 NFKSKLKKAM LSQQITKSTI ANKMRLKVLS AREQSLDGIF EETKEKLSGI ANNRDEYKPI 120
  121 LQSLIVEALL KLLEPKAIVK ALERDVDLIE SMKDDIMREY GEKAQRAPLE EIVISNDYLN 180
  181 KDLVSGGVVV SNASDKIEIN NTLEERLKLL SEEALPAIRL ELYGPSKTRK FFD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFP1 VMA13 VMA4 VMA5 VMA7 VMA8
    View Details (MIPS) Mewes HW, et al. (2004) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Gavin AC, et al. (2006) VMA13 VMA4 VMA5 VMA7 VMA8
    View Details Gavin AC, et al. (2002) ADH1 MIR1 PDC1 PEP4 RAD16 RAV1 RIM1 TDH3 TFP1 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1 VPS1 WRS1 YMR315W
    View Details Ho Y, et al. (2002) AAT2 ABP1 ACC1 ACH1 ACO1 ADH4 AFR1 AGX1 AHA1 AHP1 AIM41 AMS1 ARC1 ARF1 ARO4 ATP3 ATP4 BIK1 BUD14 CAR2 CDC33 CDC60 CLU1 COF1 COR1 CPR1 CRZ1 CYR1 CYS4 DCP1 DCP2 DNM1 DUN1 ECM10 EDC3 EDE1 EGD1 EGD2 ENP1 ERG13 ERG6 FPR1 FRS2 GAS1 GCN3 GND1 GND2 GPH1 GRX1 GUS1 HEF3 HHF1, HHF2 HHT1, HHT2 HOM2 HRR25 HSP104 HTB1 HXT7 HYP2 ILS1 IPP1 LAP4 LOC1 LRO1 LSP1 LTV1 MDH1 MDS3 MET6 MGE1 NSA1 NTA1 NTF2 NUG1 OLA1 OYE2 PDX3 PEX19 PFK1 PGM2 PIL1 PIN4 PRM2 PTC4 PUF3 RIO2 RNR2 RPA135 RPA190 RPC19 RPC40 RPM2 RSN1 SAH1 SAP185 SAP190 SAS10 SCP160 SEC2 SEC23 SEC53 SEN15 SES1 SFB3 SGM1 SIT4 SMC4 SNU13 SOD1 TEF4 TFP1 THS1 TIF1, TIF2 TMA19 TMA29 TRP5 TSA2 TSR1 UBA1 URE2 VMA4 VMA5 WTM1 YBR225W YER138C YNK1
    View Details Qiu et al. (2008) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VMA9 VPH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VMA4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] Pfam 92.522879 ATP synthase (E/31 kDa) subunit No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle