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Protein Overview: RAV1

General Information:
Name(s) found: RAV1 / YJR033C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1357 amino acids

    Gene Ontology:
    Cellular Component: RAVE complex [IPILink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    extrinsic to membrane [IDALink to PubMed article]
    Biological Process: early endosome to late endosome transport [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of protein complex assembly [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    vacuolar acidification [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNFLPGRP NATPQTACQA TWQNHTIFAY CSGNNLIILT NKFTRLQTIY TQSDCTAVDI  60
   61 NSQNGFIALS FHNRVLIYKP IHQIMQNPKW TQCCQLFHDD TPVNCLRWSS DNELAIGSDF 120
  121 LSFWKIKDNF GVYQPILQWN QKQPKPVYNV IISQDSQLIV SIGKYDCNAK LWKRVSIVGE 180
  181 QAIFNLTMLP HPKPITAMRW KKEPDQVSKN NTASHALYTL CEDKVLRIWS CFEMEKNHTV 240
  241 QIWGEVPLSP TQKFCVIIDN WIIRQTLSVK DSEIFDISDS DIVILGSMTG EMEVLALNNL 300
  301 SQDPPKPMTK KTISHKKVKK ATMLNDTRYL YLPEIQPYDN VKGKLSFLVH DLQGVIRHLL 360
  361 IDILQLINNK TEDLSAALEH KFTGHNKSVQ KLVRSSDGEA LLTTSRFSEN GVWYPQKLNH 420
  421 GVSLRLQNTI QTESPIKFAV VHELGKQVIC LLENGALQAW ECPTNRKEDS EQKQSYLRVE 480
  481 TRLKEEKKIH PIVMLNTPEP KHSHERHFTA LIFSDGSIKA FEVSLTRGIF EVKSDSLDID 540
  541 GDDIYKISII DPVHQTFVSN RPLISLITKK GLTRTYKAIV NYNDRHVQWI KACEINTGIM 600
  601 NCTCIRGSST GKLCIVNSTG KVMSLWDLNR GVLEYEETFH NPIEDIDWTS TEYGQSIVSI 660
  661 GFTGYALLYT QLRYDYTNNT PSYLPIEKID ITAHTAHNIG DSVWMKNGTF VVASGNQFYI 720
  721 KDKSLDLTDP FTYQSIGSRK ILSNDILHLS SVLNGPLPVY HPQFLIQAIY ANKLQLVKEL 780
  781 LLRLFLALRK LDFESQDVSN LDSNLGMDPL KYFIAKDRDY PVESFPDPYP CFNKTVSLAL 840
  841 TEQLTKTTLP YLTRHQQITL ITVIEAVDEV TKNENIVDYN GVRFLLGVKL FLSHKNIQKS 900
  901 ILMRDVSWAL HSDNKEILLS SIDRHITSWN RAREYRIAYW IKEQDLVKKF EDIAKYEFSK 960
  961 DDKRDPSRCA IFYLALKKKQ ILLSLWKMAI GHPEQQKMVR FISNDFTVPR WRTAALKNAF1020
 1021 VLLSKHRYMD AAVFFLLTDS LKDCVNVLCK QVHDMDLAIG VCRVYEGDNG PVLGELLTAQ1080
 1081 MLPETIKEND RWKASFIYWK LRKQEVAIKA LLTAPIDLEN NSSIVDKEVC VNRSFLVEDP1140
 1141 ALLYLYNHLR NRNLKYFIGS LNVEAKIECT LILRVTDILC RMGCNYLAVS LVKNWKFIER1200
 1201 NSIPVQKLLK SPTKDRAYSA IGAMASEPIS TARMRPSLFD KFGSPSASDI ESPNPKLPNS1260
 1261 LLDDFLQPPP NSTSSNSLAQ SSSSAPRSIL DEFVSPSYSQ HKENLTPKAP NDSVGETDNS1320
 1321 ENRKDKLSKD ILDDLSSQKP QKPKKSAITK NLLDDFV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RAV1 VPS72
    View Details Krogan NJ, et al. (2006) RAV1 RAV2
    View Details Gavin AC, et al. (2002) RAV1 TFP1 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Qiu et al. (2008) RAV1 RAV2 SKP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RAV1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] PSI-BLAST 38.045757 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [99..498] PSI-BLAST 42.69897 Tup1, C-terminal domain
    3 View Details [499..827] deduced N/A No confident structure predictions are available.
    4 View Details [828..841]
    [853..989]    		 ORFEUS 9.54 (+)-bornyl diphosphate synthase
    5 View Details [842..852]
    [990..1113]    		 ORFEUS 9.54 (+)-bornyl diphosphate synthase
    6 View Details [1114..1357] deduced N/A No confident structure predictions are available.
    7 View Details [1199..1357] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.79788997337153 bayes_pls_golite062009
  • GTPase activity
    		•  1.66665311782591 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • protein binding
    		•  1.11897341394404 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • hydrolase activity
    		•  0.28424525033024 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.203853592066275 bayes_pls_golite062009
    		• 0.13986688456512 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle