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Protein Overview: VPS72

General Information:
Name(s) found: VPS72 / YDR485C [SGD]
Description(s) found:
Found 19 descriptions.
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  • Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 795 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Swr1 complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: chromatin remodeling [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    histone exchange [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: histone binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEGADKSL DTNTEFIIQT RSRRSNAGNK LQKLLEQELR DIESTKRQIS SYKNGNDDEE  60
   61 DEIGLLFQED EDDEDFEMMA KDDDDEGEEK EDETQSIRKE PSQASSEQAA DDLMFSSSES 120
  121 EDSSNENDED AEEKEIRRQE LLSRKKRNKR LQKGPVVIKK QKPKPKSGEA IPRSHHTHEQ 180
  181 LNAETLLLNT RRTSKRSSVM ENTMKVYEKL SKAEKKRKII QERIRKHKEQ ESQHMLTQEE 240
  241 RLRIAKETEK LNILSLDKFK EQEVWKKENR LALQKRQKQK FQPNETILQF LSTAWLMTPA 300
  301 MELEDRKYWQ EQLNKRDKKK KKYPRKPKKN LNLGKQDASD DKKRESEESI KNDGDVNSLG 360
  361 ENSSSVHNQK RIEETSTNDT VEGESSPDAA VSRVNSDELK PTALPDVTLD AIANKQSTVD 420
  421 EAPNSQPQKN IITNEQKITN VGEPIQNLHN EEIKDEMVSA LESRENTFEN SSPAAQVVSQ 480
  481 RDNSATPTPS NSTGTEDTIL ISPDTDIKGE PEPCLKTEGI ENLSHNVPQE TKSNTDVSFL 540
  541 KQVTFTDHPQ VAIIDTEESP SKKDTANVDE SSAENSLSTQ TYEGPEQLTS RNFVTLYDFP 600
  601 NAPPNLKDFN TNLFGDRWSY TNGLSATQRP QDMKTVFHSI LPSPPQSSVP SPTVDISLDL 660
  661 SALANFPSFG EYDKKIVHQI NTEINKDLEI KIKTQPPTGV FLANGIRKKC LITNKECQYF 720
  721 DPRTGVPYSD VEAYKIIQRI QDPISKEEGR SDIKRDETTN EDSDDQVRFK WFGFKNGGIY 780
  781 LDLSQRPAKG VPEGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP4 ARP6 RAV1 RVB1 RVB2 SWC3 SWC4 SWC5 SWC7 SWR1 VPS71 VPS72 YAF9
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
    View Details Qiu et al. (2008) ARP6 SWC4 VPS71 VPS72 YAF9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS72 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..365] PSI-BLAST 25.69897 Heavy meromyosin subfragment
    2 View Details [366..623] deduced N/A No confident structure predictions are available.
    3 View Details [624..795] MSA 3.177995 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle