Protein Overview: SWR1

General Information:
Name(s) found:	SWR1 / YDR334W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [SGD]
Organism:	Saccharomyces cerevisiae
Length:	1514 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] Swr1 complex [IDA ]
Biological Process:	chromatin remodeling [IDA][IGI][IMP] histone exchange [IMP]
Molecular Function:	structural molecule activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSRKSHAK DKKAGGEQDL ADLKFRYDLL TNELFHLREF VSLVDYDPTH FNDSESFQKF  60
   61 LRETHLSLEE RGEKFTDDVA KKGTNGDLTR RRRNLRTSTV VSSETTNEKK GDIELKLESI 120
  121 APLVRNKCEE LKYKLSDHSN RKSIVPQKRP IQHLKKREAA KSLKFKSERK ENPLPLHEHI 180
  181 AEERYDHIAK VEEPSEAFTI KCPSDDSSFE NTSEHYSDNF YFTTSSEEED IKKKRGRKKK 240
  241 KPRIKLVVHP PKQTITNPLH VVKPGYESLH EYIASFKSLE DDLTLEEYNK YIDEQRRLLS 300
  301 RLKKGIENGA LKYDKETDSL QPITSKEIKT IITYKPDPIS YFYKQQDLQI HTDHLINQGI 360
  361 HMSKLFRSST KARIARAKKV SQMIEQHFKH VAGAEERKAK EEERHKKSLA RFAVQAVKKR 420
  421 WNMAEKAYRI LRKDEEEQLK RIEGKQHLSK MLEKSTQLLE AQLNQVNDDG RSSTPSSDSN 480
  481 DVLSESDDDM DDELSTSSDE DEEVDADVGL ENSPASTEAT PTDESLNLIQ LKEKYGHFNG 540
  541 SSTVYDSRNK DEKFPTLDKH ESSSSESSVM TGEESSIYSS SENESQNEND RESDDKTPSV 600
  601 GLSALFGKGE ESDGDLDLDD SEDFTVNSSS VEGEELEKDQ VDNSAATFER AGDFVHTQNE 660
  661 NRDDIKDVEE DAETKVQEEQ LSVVDVPVPS LLRGNLRTYQ KQGLNWLASL YNNHTNGILA 720
  721 DEMGLGKTIQ TISLLAYLAC EKENWGPHLI VVPTSVLLNW EMEFKRFAPG FKVLTYYGSP 780
  781 QQRKEKRKGW NKPDAFHVCI VSYQLVVQDQ HSFKRKRWQY MVLDEAHNIK NFRSTRWQAL 840
  841 LNFNTQRRLL LTGTPLQNNL AELWSLLYFL MPQTVIDGKK VSGFADLDAF QQWFGRPVDK 900
  901 IIETGQNFGQ DKETKKTVAK LHQVLRPYLL RRLKADVEKQ MPAKYEHIVY CKLSKRQRFL 960
  961 YDDFMSRAQT KATLASGNFM SIVNCLMQLR KVCNHPNLFE VRPILTSFVL EHCVASDYKD1020
 1021 VERTLLKLFK KNNQVNRVDL DFLNLVFTLN DKDLTSYHAE EISKLTCVKN FVEEVNKLRE1080
 1081 TNKQLQEEFG EASFLNFQDA NQYFKYSNKQ KLEGTVDMLN FLKMVNKLRC DRRPIFGKNL1140
 1141 IDLLTKDRRV KYDKSSIIDN ELIKPLQTRV LDNRKIIDTF AVLTPSAVSL DMRKLALGLN1200
 1201 DDSSVGENTR LKVMQNCFEV SNPLHQLQTK LTIAFPDKSL LQYDCGKLQK LAILLQQLKD1260
 1261 NGHRALIFTQ MTKVLDVLEQ FLNYHGYLYM RLDGATKIED RQILTERFNT DSRITVFILS1320
 1321 SRSGGLGINL TGADTVIFYD SDWNPAMDKQ CQDRCHRIGQ TRDVHIYRFV SEHTIESNIL1380
 1381 KKANQKRQLD NVVIQEGDFT TDYFSKLSVR DLLGSELPEN ASGGDKPLIA DADVAAKDPR1440
 1441 QLERLLAQAE DEDDVKAANL AMREVEIDND DFDESTEKKA ANEEEENHAE LDEYEGTAHV1500
 1501 DEYMIRFIAN GYYY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARP4 ARP6 BDF1 RVB1 RVB2 SWC3 SWC4 SWC5 SWC7 SWR1 VPS71 VPS72 YAF9
View Details	Hazbun TR, et al. (2003)		ARP4 EAF1 EAF5 EPL1 ESA1 RVB1 RVB2 SWC4 SWR1 TRA1 YAF9 YNG2
View Details	Krogan NJ, et al. (2006)		ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	SWC4	No Comments	Hazbun TR, et al. (2003)
View Run	SWC4	No Comments	Hazbun TR, et al. (2003)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD1	SWR1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	SWR1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..346]	PSI-BLAST	3.154902	Heavy meromyosin subfragment
2	View Details	[347..632]	deduced	N/A	No confident structure predictions are available.
3	View Details	[633..1005]	Pfam	114.004365	SNF2 family N-terminal domain No confident structure predictions are available.
4	View Details	[1006..1237]	deduced	N/A	No confident structure predictions are available.
5	View Details	[1238..1360]	Pfam	22.031517	Helicase conserved C-terminal domain No confident structure predictions are available.
6	View Details	[1361..1514]	MSA	4.202995	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	2.68677407235528	bayes_pls_golite062009
nucleic acid binding	2.55499128961037	bayes_pls_golite062009
telomeric DNA binding	2.51555240517937	bayes_pls_golite062009
single-stranded telomeric DNA binding	2.42617682290608	bayes_pls_golite062009
structural constituent of ribosome	2.05166830102408	bayes_pls_golite062009
structural molecule activity	1.88289765635623	bayes_pls_golite062009
DNA binding	1.82124247082886	bayes_pls_golite062009
structure-specific DNA binding	1.44779598506198	bayes_pls_golite062009
ribonuclease activity	1.29444332911502	bayes_pls_golite062009
single-stranded DNA binding	1.28974640221593	bayes_pls_golite062009
hydrolase activity	0.724860465280978	bayes_pls_golite062009
DNA-dependent ATPase activity	0.498105565279986	bayes_pls_golite062009
translation regulator activity	0.433181719163502	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.385829426544547	bayes_pls_golite062009
protein binding	0.360033745054291	bayes_pls_golite062009
exoribonuclease activity	0.249698955842391	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.227933240776321	bayes_pls_golite062009
chromatin binding	0.1876135725713	bayes_pls_golite062009
nuclease activity	0.1667307589287	bayes_pls_golite062009
translation initiation factor activity	0.12942560136182	bayes_pls_golite062009
telomerase inhibitor activity	0.111973370145519	bayes_pls_golite062009
DNA-directed RNA polymerase activity	0.0926650185896696	bayes_pls_golite062009
RNA polymerase activity	0.0926650185896696	bayes_pls_golite062009

Term	Confidence	Notes
DNA-dependent ATPase activity	2.58390156971125	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
binding	2.4974940028864	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.85030653553169	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.84811666933472	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.0904709750093	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
histone acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleic acid binding	0.775560967092349	bayes_pls_golite062009
microtubule motor activity	0.60036517876321	bayes_pls_golite062009
pyrophosphatase activity	0.540750418412449	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.517457589081898	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
purine nucleotide binding	0.428373955572763	bayes_pls_golite062009
purine ribonucleotide binding	0.424644011903671	bayes_pls_golite062009
ribonucleotide binding	0.424583288440993	bayes_pls_golite062009
nucleotide binding	0.422354428195324	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
DNA helicase activity	0.3665939534705	bayes_pls_golite062009
helicase activity	0.243380876721902	bayes_pls_golite062009
DNA binding	0.226110787229935	bayes_pls_golite062009
ATP binding	0.04834397972685	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0315266818880198	bayes_pls_golite062009
adenyl ribonucleotide binding	0.0149501427627318	bayes_pls_golite062009
structural constituent of ribosome	0.0102645529518819	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009
adenyl nucleotide binding	0.00365326483311895	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2