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Protein Overview: SWC4

General Information:
Name(s) found: SWC4 / YGR002C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 476 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    NuA4 histone acetyltransferase complex [IPILink to PubMed articleLink to PubMed article]
    Swr1 complex [IDALink to PubMed articleLink to PubMed article]
    histone acetyltransferase complex [IPILink to PubMed article]
    Biological Process: chromatin modification [IPILink to PubMed article]
    DNA repair [IDALink to PubMed article]
    chromatin remodeling [IDALink to PubMed article][IPILink to PubMed article]
    histone exchange [IPILink to PubMed article]
    histone acetylation [IPILink to PubMed article]
    Molecular Function: DNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSDIFDVL NIKQKSRSPT NGQVSVPSSS AANRPKPQVT GMQRELFNLL GENQPPVVIK  60
   61 SGNNFKEKML STSKPSPWSF VEFKANNSVT LRHWVKGSKE LIGDTPKESP YSKFNQHLSI 120
  121 PSFTKEEYEA FMNENEGTQK SVESEKNHNE NFTNEKKDES KNSWSFEEIE YLFNLCKKYD 180
  181 LRWFLIFDRY SYNNSRTLED LKEKFYYTCR NYFKASDPSN PLLSSLNFSA EKEIERKKYL 240
  241 QRLLSRSAAE IAEEEALVVE SKKFEMAAKR TLAERESLLR LLDSPHSDQT ITQYLTSQGM 300
  301 SQLYNALLAD KTRKRKHDLN IPENPWMKQQ QQFAQHRQLQ QLNVKKSEVK ENLSPKKTKR 360
  361 QRQEMQTALK RKSESAYAEQ LLKDFNSDER KALGVITHGE KLSPGVYLRS TKLSTFKPAL 420
  421 QNKILAILQE LSLPSRPVMP SFDVMERQEE LLKKINTLID LKKHVDKYEA GMSITK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP4 ARP6 BDF1 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1 ESA1 RVB1 RVB2 SRP1 SWC3 SWC4 SWC5 SWC7 SWR1 VPS72 YAF9 YNG2
    View Details Hazbun TR, et al. (2003) ARP4 EAF1 EAF5 EPL1 ESA1 RVB1 RVB2 SWC4 SWR1 TRA1 YAF9 YNG2
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
    View Details Ho Y, et al. (2002) ARP4 FAA2 HFI1 RPO31 SPT7 STB4 SWC4 SWI5 TRA1
    View Details Qiu et al. (2008) ARP4 ARP6 EPL1 SPT3 SWC4 TAF10 TAF12 VPS71 VPS72

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SWC4 SPO21 2 Hazbun TR, et al. (2003)
    View Screen SWC4 EAF1 2 Hazbun TR, et al. (2003)
    View Screen SWC4 SPP382 2 Hazbun TR, et al. (2003)
    View Screen SWC4 YNL092W 2 Hazbun TR, et al. (2003)
    View Screen SWC4 SPO21 2 Hazbun TR, et al. (2003)
    View Screen SWC4 NIP100 2 Hazbun TR, et al. (2003)
    View Screen SWC4 YNL092W 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SWC4 and SPC42 Hazbun TR, et al. (2003)
    View Data SWC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..160] deduced N/A No confident structure predictions are available.
    2 View Details [161..221] Pfam 3.568636 Myb-like DNA-binding domain No confident structure predictions are available.
    3 View Details [222..476] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • histone acetyltransferase activity
    		•  5.78270240334849 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.78270240334849 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.53404381270892 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  4.38345537045529 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.81897719505269 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35931919126926 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31384699789032 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.09869056563841 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05971315776284 bayes_pls_golite062009
  • DNA binding
    		•  2.98143466641891 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.85666780317594 bayes_pls_golite062009
  • binding
    		•  2.77786931095369 bayes_pls_golite062009
  • transcription factor activity
    		•  2.3234819540139 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.5871271401402 bayes_pls_golite062009
  • chromatin binding
    		•  1.46306211220814 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.23729321119532 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.23476914879396 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.18710646783152 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.02200659886159 bayes_pls_golite062009
  • protein binding
    		•  1.00288283679871 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.700409976805769 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.658518317984762 bayes_pls_golite062009
  • transcription activator activity
    		•  0.58607600202198 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.559482273209868 bayes_pls_golite062009
  • deacetylase activity
    		•  0.534082291544628 bayes_pls_golite062009
  • histone binding
    		•  0.489784140732052 bayes_pls_golite062009
  • transcription factor binding
    		•  0.270053518126008 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.244471307852075 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.233668696331578 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.192832786095412 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.151335943405565 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0110175210304684 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle