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Protein Overview: YNG2

General Information:
Name(s) found: YNG2 / YHR090C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    NuA4 histone acetyltransferase complex [IPILink to PubMed article]
    Piccolo NuA4 histone acetyltransferase complex [IDALink to PubMed article]
    histone acetyltransferase complex [IDALink to PubMed article]
    Biological Process: chromatin modification [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    DNA repair [IDALink to PubMed article]
    histone acetylation [IDALink to PubMed article]
    Molecular Function: enzyme activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPSLVLEQT IQDVSNLPSE FRYLLEEIGS NDLKLIEEKK KYEQKESQIH KFIRQQGSIP  60
   61 KHPQEDGLDK EIKESLLKCQ SLQREKCVLA NTALFLIARH LNKLEKNIAL LEEDGVLAPV 120
  121 EEDGDMDSAA EASRESSVVS NSSVKKRRAA SSSGSVPPTL KKKKTSRTSK LQNEIDVSSR 180
  181 EKSVTPVSPS IEKKIARTKE FKNSRNGKGQ NGSPENEEED KTLYCFCQRV SFGEMVACDG 240
  241 PNCKYEWFHY DCVNLKEPPK GTWYCPECKI EMEKNKLKRK RN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP4 BDF1 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1 ESA1 SWC4 YAF9 YNG2
    View Details Hazbun TR, et al. (2003) ARP4 EAF1 EAF5 EPL1 ESA1 RVB1 RVB2 SWC4 SWR1 TRA1 YAF9 YNG2
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YNG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..35]
    [81..206]    		 ORFEUS 7.77 Variant surface glycoprotein (N-terminal domain)
    2 View Details [36..80] ORFEUS 7.77 Variant surface glycoprotein (N-terminal domain)
    3 View Details [207..282] PSI-BLAST 5.0 Williams-Beuren syndrome transcription factor, WSTF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • lysine N-acetyltransferase activity
    		•  7.10262960897544 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  7.10262960897544 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  5.0952093808777 bayes_pls_golite062009
    		• 4.93977737347339 bayes_pls_golite062009
    		• 4.75659254650148 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.73470737654883 bayes_pls_golite062009
  • acetyltransferase activity
    		•  4.29938591960121 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.59302841227183 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.54892905221507 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.34035867339622 bayes_pls_golite062009
  • histone binding
    		•  3.01402804224903 bayes_pls_golite062009
  • binding
    		•  2.78627791259335 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.85191754801422 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.81121374048292 bayes_pls_golite062009
  • methylated histone residue binding
    		•  1.80051107279585 bayes_pls_golite062009
  • protein binding
    		•  1.6308789519356 bayes_pls_golite062009
  • DNA binding
    		•  1.25742999570208 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.20287476673928 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08856770172893 bayes_pls_golite062009
  • chromatin binding
    		•  1.0360039180364 bayes_pls_golite062009
  • deacetylase activity
    		•  0.912057424750107 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.476506467104495 bayes_pls_golite062009
  • protein kinase activity
    		•  0.405766438875014 bayes_pls_golite062009
  • nucleosome binding
    		•  0.252195940764881 bayes_pls_golite062009
  • transcription factor activity
    		•  0.157987030393304 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.14235705491362 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0901653273812402 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  0.0490968711985191 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.040477854291574 bayes_pls_golite062009
  • kinase activity
    		•  0.00387875923819597 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle