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Protein Overview: ARP6

General Information:
Name(s) found: ARP6 / YLR085C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 438 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Swr1 complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: chromatin remodeling [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    histone exchange [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: nucleosome binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPPIVIDN GSYEIKFGPS TNKKPFRALN ALAKDKFGTS YLSNHIKNIK DISSITFRRP  60
   61 HELGQLTLWE LESCIWDYCL FNPSEFDGFD LKEGKGHHLV ASESCMTLPE LSKHADQVIF 120
  121 EEYEFDSLFK SPVAVFVPFT KSYKGEMRTI SGKDEDIDIV RGNSDSTNST SSESKNAQDS 180
  181 GSDYHDFQLV IDSGFNCTWI IPVLKGIPYY KAVKKLDIGG RFLTGLLKET LSFRHYNMMD 240
  241 ETILVNNIKE QCLFVSPVSY FDSFKTKDKH ALEYVLPDFQ TSFLGYVRNP RKENVPLPED 300
  301 AQIITLTDEL FTIPETFFHP EISQITKPGI VEAILESLSM LPEIVRPLMV GNIVCTGGNF 360
  361 NLPNFAQRLA AELQRQLPTD WTCHVSVPEG DCALFGWEVM SQFAKTDSYR KARVTREEYY 420
  421 EHGPDWCTKH RFGYQNWI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP4 ARP6 BDF1 RVB1 RVB2 SWC3 SWC4 SWC5 SWC7 SWR1 VPS71 VPS72 YAF9
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
    View Details Qiu et al. (2008) ARP4 ARP6 SWC4 VPS71 VPS72

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ARP6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133]
    [396..438]    		 PSI-BLAST 372.9794 Actin
    2 View Details [134..395] PSI-BLAST 372.9794 Actin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle