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Protein Overview: TRA1

General Information:
Name(s) found: TRA1 / YHR099W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 3744 amino acids

    Gene Ontology:
    Cellular Component: NuA4 histone acetyltransferase complex [IPILink to PubMed article]
    SLIK (SAGA-like) complex [IPILink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    histone acetyltransferase complex [IPILink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article]
    histone acetylation [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: histone acetyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLTEQIEQF ASRFRDDDAT LQSRYSTLSE LYDIMELLNS PEDYHFFLQA VIPLLLNQLK  60
   61 EVPISYDAHS PEQKLRNSML DIFNRCLMNQ TFQPYAMEVL EFLLSVLPKE NEENGILCMK 120
  121 VLTTLFKSFK SILQDKLDSF IRIIIQIYKN TPNLINQTFY EAGKAEQGDL DSPKEPQADE 180
  181 LLDEFSKNDE EKDFPSKQSS TEPRFENSTS SNGLRSSMFS FKILSECPIT MVTLYSSYKQ 240
  241 LTSTSLPEFT PLIMNLLNIQ IKQQQEAREQ AESRGEHFTS ISTEIINRPA YCDFILAQIK 300
  301 ATSFLAYVFI RGYAPEFLQD YVNFVPDLII RLLQDCPSEL SSARKELLHA TRHILSTNYK 360
  361 KLFLPKLDYL FDERILIGNG FTMHETLRPL AYSTVADFIH NIRSELQLSE IEKTIKIYTG 420
  421 YLLDESLALT VQIMSAKLLL NLVERILKLG KENPQEAPRA KKLLMIIIDS YMNRFKTLNR 480
  481 QYDTIMKYYG RYETHKKEKA EKLKNSIQDN DKESEEFMRK VLEPSDDDHL MPQPKKEDIN 540
  541 DSPDVEMTES DKVVKNDVEM FDIKNYAPIL LLPTPTNDPI KDAFYLYRTL MSFLKTIIHD 600
  601 LKVFNPPPNE YTVANPKLWA SVSRVFSYEE VIVFKDLFHE CIIGLKFFKD HNEKLSPETT 660
  661 KKHFDISMPS LPVSATKDAR ELMDYLAFMF MQMDNATFNE IIEQELPFVY ERMLEDSGLL 720
  721 HVAQSFLTSE ITSPNFAGIL LRFLKGKLKD LGNVDFNTSN VLIRLFKLSF MSVNLFPNIN 780
  781 EVVLLPHLND LILNSLKYST TAEEPLVYFY LIRTLFRSIG GGRFENLYRS IKPILQVLLQ 840
  841 SLNQMILTAR LPHERELYVE LCITVPVRLS VLAPYLPFLM KPLVFALQQY PDLVSQGLRT 900
  901 LELCIDNLTA EYFDPIIEPV IDDVSKALFN LLQPQPFNHA ISHNVVRILG KLGGRNRQFL 960
  961 KPPTDLTEKT ELDIDAIADF KINGMPEDVP LSVTPGIQSA LNILQSYKSD IHYRKSAYKY1020
 1021 LTCVLLLMTK SSAEFPTNYT ELLKTAVNSI KLERIGIEKN FDLEPTVNKR DYSNQENLFL1080
 1081 RLLESVFYAT SIKELKDDAM DLLNNLLDHF CLLQVNTTLL NKRNYNGTFN IDLKNPNFML1140
 1141 DSSLILDAIP FALSYYIPEV REVGVLAYKR IYEKSCLIYG EELALSHSFI PELAKQFIHL1200
 1201 CYDETYYNKR GGVLGIKVLI DNVKSSSVFL KKYQYNLANG LLFVLKDTQS EAPSAITDSA1260
 1261 EKLLIDLLSI TFADVKEEDL GNKVLENTLT DIVCELSNAN PKVRNACQKS LHTISNLTGI1320
 1321 PIVKLMDHSK QFLLSPIFAK PLRALPFTMQ IGNVDAITFC LSLPNTFLTF NEELFRLLQE1380
 1381 SIVLADAEDE SLSTNIQKTT EYSTSEQLVQ LRIACIKLLA IALKNEEFAT AQQGNIRIRI1440
 1441 LAVFFKTMLK TSPEIINTTY EALKGSLAEN SKLPKELLQN GLKPLLMNLS DHQKLTVPGL1500
 1501 DALSKLLELL IAYFKVEIGR KLLDHLTAWC RVEVLDTLFG QDLAEQMPTK IIVSIINIFH1560
 1561 LLPPQADMFL NDLLLKVMLL ERKLRLQLDS PFRTPLARYL NRFHNPVTEY FKKNMTLRQL1620
 1621 VLFMCNIVQR PEAKELAEDF EKELDNFYDF YISNIPKNQV RVVSFFTNMV DLFNTMVITN1680
 1681 GDEWLKKKGN MILKLKDMLN LTLKTIKENS FYIDHLQLNQ SIAKFQALYL RFTELSERDQ1740
 1741 NPLLLDFIDF SFSNGIKASY SLKKFIFHNI IASSNKEKQN NFINDATLFV LSDKCLDARI1800
 1801 FVLKNVINST LIYEVATSGS LKSYLVEDKK PKWLELLHNK IWKNSNAILA YDVLDHHDLF1860
 1861 RFELLQLSAI FIKADPEIIA EIKKDIIKFC WNFIKLEDTL IKQSAYLVTS YFISKFDFPI1920
 1921 KVVTQVFVAL LRSSHVEARY LVKQSLDVLT PVLHERMNAA GTPDTWINWV KRVMVENSSS1980
 1981 QNNILYQFLI SHPDLFFNSR DLFISNIIHH MNKITFMSNS NSDSHTLAID LASLILYWEN2040
 2041 KTLEITNVNN TKTDSDGDVV MSDSKSDINP VEADTTAIIV DANNNSPISL HLREACTAFL2100
 2101 IRYVCASNHR AIETELGLRA INILSELISD KHWTNVNVKL VYFEKFLIFQ DLDSENILYY2160
 2161 CMNALDVLYV FFKNKTKEWI MENLPTIQNL LEKCIKSDHH DVQEALQKVL QVIMKAIKAQ2220
 2221 GVSVIIEEES PGKTFIQMLT SVITQDLQET SSVTAGVTLA WVLFMNFPDN IVPLLTPLMK2280
 2281 TFSKLCKDHL SISQPKDAMA LEEARITTKL LEKVLYILSL KVSLLGDSRR PFLSTVALLI2340
 2341 DHSMDQNFLR KIVNMSRSWI FNTEIFPTVK EKAAILTKML AFEIRGEPSL SKLFYEIVLK2400
 2401 LFDQEHFNNT EITVRMEQPF LVGTRVEDIG IRKRFMTILD NSLERDIKER LYYVIRDQNW2460
 2461 EFIADYPWLN QALQLLYGSF NREKELSLKN IYCLSPPSIL QEYLPENAEM VTEVNDLELS2520
 2521 NFVKGHIASM QGLCRIISSD FIDSLIEIFY QDPKAIHRAW VTLFPQVYKS IPKNEKYGFV2580
 2581 RSIITLLSKP YHTRQISSRT NVINMLLDSI SKIESLELPP HLVKYLAISY NAWYQSINIL2640
 2641 ESIQSNTSID NTKIIEANED ALLELYVNLQ EEDMFYGLWR RRAKYTETNI GLSYEQIGLW2700
 2701 DKAQQLYEVA QVKARSGALP YSQSEYALWE DNWIQCAEKL QHWDVLTELA KHEGFTDLLL2760
 2761 ECGWRVADWN SDRDALEQSV KSVMDVPTPR RQMFKTFLAL QNFAESRKGD QEVRKLCDEG2820
 2821 IQLSLIKWVS LPIRYTPAHK WLLHGFQQYM EFLEATQIYA NLHTTTVQNL DSKAQEIKRI2880
 2881 LQAWRDRLPN TWDDVNMWND LVTWRQHAFQ VINNAYLPLI PALQQSNSNS NINTHAYRGY2940
 2941 HEIAWVINRF AHVARKHNMP DVCISQLARI YTLPNIEIQE AFLKLREQAK CHYQNMNELT3000
 3001 TGLDVISNTN LVYFGTVQKA EFFTLKGMFL SKLRAYEEAN QAFATAVQID LNLAKAWAQW3060
 3061 GFFNDRRLSE EPNNISFASN AISCYLQAAG LYKNSKIREL LCRILWLISI DDASGMLTNA3120
 3121 FDSFRGEIPV WYWITFIPQL LTSLSHKEAN MVRHILIRIA KSYPQALHFQ LRTTKEDFAV3180
 3181 IQRQTMAVMG DKPDTNDRNG RRQPWEYLQE LNNILKTAYP LLALSLESLV AQINDRFKST3240
 3241 TDEDLFRLIN VLLIDGTLNY NRLPFPRKNP KLPENTEKNL VKFSTTLLAP YIRPKFNADF3300
 3301 IDNKPDYETY IKRLRYWRRR LENKLDRASK KENLEVLCPH LSNFHHQKFE DIEIPGQYLL3360
 3361 NKDNNVHFIK IARFLPTVDF VRGTHSSYRR LMIRGHDGSV HSFAVQYPAV RHSRREERMF3420
 3421 QLYRLFNKSL SKNVETRRRS IQFNLPIAIP LSPQVRIMND SVSFTTLHEI HNEFCKKKGF3480
 3481 DPDDIQDFMA DKLNAAHDDA LPAPDMTILK VEIFNSIQTM FVPSNVLKDH FTSLFTQFED3540
 3541 FWLFRKQFAS QYSSFVFMSY MMMINNRTPH KIHVDKTSGN VFTLEMLPSR FPYERVKPLL3600
 3601 KNHDLSLPPD SPIFHNNEPV PFRLTPNIQS LIGDSALEGI FAVNLFTISR ALIEPDNELN3660
 3661 TYLALFIRDE IISWFSNLHR PIIENPQLRE MVQTNVDLII RKVAQLGHLN STPTVTTQFI3720
 3721 LDCIGSAVSP RNLARTDVNF MPWF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 ARP4 EAF1 EAF3 EAF5 EPL1 ESA1 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF5 TAF6 TRA1 YAF9
    View Details Hazbun TR, et al. (2003) ARP4 EAF1 EAF5 EPL1 ESA1 RVB1 RVB2 SWC4 SWR1 TRA1 YAF9 YNG2
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 ESA1 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
    View Details Gavin AC, et al. (2002) ACT1 ADH1 ARP4 EAF1 EAF3 EAF5 EPL1 ESA1 HHF1, HHF2 TRA1 YAF9 YAP1
    View Details Ho Y, et al. (2002) ADA2 ARP4 ATE1 CBF5 CBP2 CCM1 CDC33 CIC1 CKA2 DBP7 DIS3 EAF1 EAF3 ENP2 EPL1 ESA1 FAA2 FET4 FIP1 GBP2 GCN5 HAS1 HFI1 HMO1 HPR1 HRR25 HTB2 IMD1 IMD3 ISA1 KAP95 KRE33 KRI1 MES1 MFT1 MGM101 MSS116 NAM8 NOC2 NOP12 NOP6 NPL3 NUP1 NUP2 NUP60 PAP1 PCT1 PET127 POL5 POR1 PRP43 PUF6 PWP1 REB1 RLI1 RNT1 RPO31 RRP12 RRP4 RRP43 RRP5 RRP6 RTT103 SAP185 SGF29 SIF2 SIN3 SIT4 SNU56 SPT7 SRP1 STB4 STO1 SWC4 SWI5 TAF14 TAF4 TAF6 THO2 TIF4631 TIP41 TRA1 TSR1 TUF1 UBP8 UME1 URB1 URB2 UTP10 UTP20 YPP1 YPR090W YRA1 YTM1
    View Details Qiu et al. (2008) ACT1 ADA2 ARP4 EAF3 EAF7 EPL1 ESA1 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 SUS1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF3 TAF5 TAF6 TAF9 TRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..522] MSA 2.009859 View MSA. No confident structure predictions are available.
    2 View Details [523..1347] deduced N/A No confident structure predictions are available.
    3 View Details [1348..2109] MSA 1.016001 View MSA. No confident structure predictions are available.
    4 View Details [2110..2411] deduced N/A No confident structure predictions are available.
    5 View Details [2412..2597] MSA 1.031983 View MSA. No confident structure predictions are available.
    6 View Details [2598..3193] Pfam 204.744727 FAT domain No confident structure predictions are available.
    7 View Details [3194..3315] PSI-BLAST 79.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    8 View Details [3316..3420]
    [3446..3461]    		 PSI-BLAST 79.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    9 View Details [3421..3445]
    [3462..3708]    		 PSI-BLAST 79.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    10 View Details [3709..3744] Pfam 11.79588 FATC domain No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle