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Protein Overview: SPT8

General Information:
Name(s) found: SPT8 / YLR055C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 602 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article][IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: transcription cofactor activity [IMPLink to PubMed article][IPILink to PubMed article]
    TATA-binding protein binding [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEVDDILIN NQVVDDEEDD EEMLSGLEND SKQDLEGNDD GGEDEEDDDD DDEDDDDDED  60
   61 EREDDDEQED DDGEDDAARM DKTATPTNEH QHDEQKAAAA GAGGAGDSGD AVTKIGSEDV 120
  121 KLSDVDGGVG SREASSSTHE ASANGEVYEY YKHMLNAAQI ADSYNIYPTA AIPIQTHVNA 180
  181 LAVSRGLKYL FLGGSDGYIR KYDLLNTLEG KLSLTILQKH SLAESIQNAG ILQSYWENEI 240
  241 PQKKSEMKLS ANKTDYEPKV SPVHSLEVQS ECLFILSGLQ NGGITMQGVR YMEGSIAHYF 300
  301 KGRNGHTQIV NILRLNGQED RFLSGSWDKR LLEWDLQTGD IVNEFKKSRS ELSSLEMRPL 360
  361 YSSVDVSGNV NSGKENENAD DDMDSLFGDE DEDEKQDAGN EPVETGDGSN GEENKEQISE 420
  421 ESLNIVYDES VFMTSGLNGS VHIWDRRMTQ SPALSLERGA GVPPWCLSAC WGVDGDHVYA 480
  481 GRRNACVEQF DLKMPSKPIH NLKLPSISGP VSCVKAMPNN KHLLCASRDN IRLYNVEIAV 540
  541 DASNSTTKSS KVPFLIVPGH HGGIISNLYL DPTSRFIIST SGNRGWQGNS TDTTLIYDID 600
  601 LE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF3 TAF5 TAF6 TAF7 TAF9 TRA1 UBP8
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Gavin AC, et al. (2006) ADA2 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
    View Details Qiu et al. (2008) ADA2 CHD1 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 SUS1 TAF10 TAF12 TAF14 TAF5 TAF6 TAF9 TFB5 TRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SPT8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] ORFEUS 7.13 No description for 1l8mA was found.
    2 View Details [67..124] ORFEUS 7.13 No description for 1l8mA was found.
    3 View Details [125..491] PSI-BLAST 84.154902 beta1-subunit of the signal-transducing G protein heterotrimer
    4 View Details [492..602] PSI-BLAST 4.30103 Quinoprotein alcohol dehydrogenase, C-terminal domain; Quinoprotein alcohol dehydrogenase, N-terminal domain
    5 View Details [379..493] FFAS03 3.62 No description for 2hesX was found.
    6 View Details [494..602] PSI-BLAST 69.69897 No description for 2ovpB was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle