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Protein Overview: TAF2

General Information:
Name(s) found: TAF2 / YCR042C [SGD]
Description(s) found:
Found 26 descriptions.
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  • TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1407 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIID complex [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: regulation of transcription involved in G1 phase of mitotic cell cycle [IMPLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSFSKNATP RAIVSESSTL HEMKFRNFRV AHEKISLDID LATHCITGSA TIIIIPLIQN  60
   61 LEYVTFDCKE MTIKDVLVEN RRCDQFIHDD PLQTNLNGLT SQNVLYSDNS IEQSHFLRSK 120
  121 FASLNEYPET DSKSQLTIKI PSSIKISLED ANALSNYTPI TPSIKTTPGF QESVFTPITL 180
  181 QIEYEIRNPK SGIKFDTVYA DKPWLWNVYT SNGEICSSAS YWVPCVDLLD EKSTWELEFS 240
  241 VPRLVKNIGT SKLIGQNGEE SEKEKEDTPE HDEEEEGKPA RVIKDEDKDS NLKNDEEGKN 300
  301 SKSKDAQDND EEEEEGESDE EEEEGEEERR NIEESNNPSL RDVIVCCSEY SNIKELPHPI 360
  361 DLTKKKCIFQ IINPVAPHHI GWAIGAFNSW SLPLISPPSV DAEDEVEEDK LRENVVDNVN 420
  421 DTMDDDIGSD IIPIQIFTLP TQETDELTVI NSTVVCQKII DFYSKEFGSY PFTCYSMVFL 480
  481 PTAPSKHMDF AALGICNTRL LYPLEVIDKA FSTTNELAWA LANQWSCVNI TPLDMNDYWC 540
  541 CLGIAGYMVF QVTKKLMGNN TYKYQLKRNS EAIVEQDFEK PPIGSTFTGS SRPISWSSKD 600
  601 LSFIQLKAPM ILHILDRRMT KTERSFGMSR VLPKIFLQAM SGDLPNNSLT SSHFQHVCER 660
  661 VNKSKLENFF NEWVYGSGVP ILRVTQRFNR KRMVIELGIR QVQDEELGHE KVVGEEGFFK 720
  721 SALDHLEHPD LNRTECFTGS MTIRIHEHDG TPYEHIVEIK DTFTKIDIQY NTKYRRLRKR 780
  781 GGGANDENGV ENNNEEKPIV VDVNCLGNVY MSPEECSRFS LTEFNRTSES NELLKQNEAF 840
  841 EWIRIDSDLE WICQMHINQP DYMFSSQLRQ DGDIEAQLEA IRYYEDVVVN GGVKSLVYSS 900
  901 ILFRTAIDER YFFGIRLAAC EALSKYVYDP DFTGGVKHLI QIFQILFCLE DSNIPKSNNF 960
  961 ENPKLYFLQC NIPKYLAKVK NENGKCPKLV KQFLLDILVY NENGENKYSD DAYVRSLIEN1020
 1021 VVKVALNEYK DKAYMEKVKT QLLRYENLVN WLSSYESLIK TTIMYAKYKL HKVGAYDFTE1080
 1081 LTGMIMHTLT LGINNGDISR ESFQNEFLMV LKIMLLEGGL KNKDALVLFT EILCFHEDSY1140
 1141 IRDKSVDVLS ECVNLVVMDG SLDTISDDIK SSVQSVHNEV KNIKSEDDIE LFLSGHYVDD1200
 1201 MKIKIEKIGR QNISGLIQIC RDMFKGYSPL KILLWDVLNL PVLSLYQRKQ IHDLVRVMYT1260
 1261 LINSFVVRLE TPRERRLVAK MNSNEEGKLD IVIKRESILK VHIKKEVTST VEAPKKANKI1320
 1321 KISLKGDKPV RKVEKQIVKP KVTSKQRKVK SHVNRMGSLP LRFVKIQQQP RVMVHLSSVP1380
 1381 YSQFVQITKV TSRSFMVKIR TKNDAKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TAF2 TAF8
    View Details (MIPS) Mewes HW, et al. (2004) TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF5 TAF6 TAF7 TAF9
    View Details Krogan NJ, et al. (2006) ESC1 ROX1 TAF2 TAF8
    View Details Gavin AC, et al. (2006) TAF2 TAF8
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 VAS1 VPS1
    View Details Qiu et al. (2008) SGF73 SPT20 SPT7 SSL2 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TFA1 TFA2 TFB1 TFB5 TFC4 TFG1 TFG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TAF2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..240] ORFEUS 11.15 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    2 View Details [241..387] PSI-BLAST 80.0 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    3 View Details [388..517] PSI-BLAST 80.0 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    4 View Details [518..689] PSI-BLAST 80.0 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    5 View Details [690..789] PSI-BLAST 80.0 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    6 View Details [790..951] MSA 2.127996 View MSA. No confident structure predictions are available.
    7 View Details [952..1407] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle