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Protein Overview: TAF12

General Information:
Name(s) found: TAF12 / YDR145W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 539 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIID complex [IDALink to PubMed article][TASLink to PubMed article]
    SLIK (SAGA-like) complex [IPILink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: chromatin modification [TASLink to PubMed article]
    protein amino acid acetylation [IPILink to PubMed article]
    histone acetylation [TASLink to PubMed article]
    chromatin organization [IPILink to PubMed article]
    regulation of transcription involved in G1 phase of mitotic cell cycle [IPILink to PubMed articleLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNPENSGV NANNNTGTGN ADAITGAQQN MVLQPRQLQE MAAKFRTLLT EARNVGETTP  60
   61 RGKELMFQAA KIKQVYDALT LNRRRQQAAQ AYNNTSNSNS SNPASIPTEN VPNSSQQQQQ 120
  121 QQQQTRNNSN KFSNMIKQVL TPEENQEYEK LWQNFQVRHT SIKEKETYLK QNIDRLEQEI 180
  181 NKQTDEGPKQ QLQEKKIELL NDWKVLKIEY TKLFNNYQNS KKTFYVECAR HNPALHKFLQ 240
  241 ESTQQQRVQQ QRVQQQQQQQ QQQQQQQQQQ QQQQQQRQGQ NQRKISSSNS TEIPSVTGPD 300
  301 ALKSQQQQQN TITATNNPRG NVNTSQTEQS KAKVTNVNAT ASMLNNISSS KSAIFKQTEP 360
  361 AIPISENIST KTPAPVAYRS NRPTITGGSA MNASALNTPA TTKLPPYEMD TQRVMSKRKL 420
  421 RELVKTVGID EGDGETVIDG DVEELLLDLA DDFVTNVTAF SCRLAKHRKS DNLEARDIQL 480
  481 HLERNWNIRI PGYSADEIRS TRKWNPSQNY NQKLQSITSD KVAAAKNNGN NVASLNTKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT15 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF5 TAF6 TAF7 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Gavin AC, et al. (2006) SPT15 TAF1 TAF11 TAF12 TAF3 TAF4 TAF9
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
    View Details Qiu et al. (2008) ADA2 AHC1 CHD1 EPL1 GAL11 GCN5 HFI1 MED1 MED2 NGG1 NUT1 NUT2 PGD1 RGR1 ROX3 SGF11 SGF29 SGF73 SIN4 SPT20 SPT3 SPT7 SPT8 SRB4 SRB6 SSL2 SUS1 SWC4 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TFA1 TFB5 TFG1 TFG2 TRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TAF12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..232] deduced N/A No confident structure predictions are available.
    2 View Details [233..405] MSA 4.013997 View MSA. No confident structure predictions are available.
    3 View Details [406..539] ORFEUS 14.64 TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  9.25279783093877 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  5.97252613675094 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.97252613675094 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  4.49886535711761 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.22222466548509 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  3.96621818094279 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.91614625961398 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.38611688546892 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.35015681315177 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.1782337747057 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.82448881874976 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.10331930589736 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009
  • histone binding
    		•  0.218942897869955 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0736756545988504 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle