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Protein Overview: REV3

General Information:
Name(s) found: REV3 / YPL167C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1504 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    zeta DNA polymerase complex [IDALink to PubMed article]
    Biological Process: mutagenesis [IGILink to PubMed article][IMPLink to PubMed article]
    DNA repair [TASLink to PubMed article]
    Molecular Function: nucleotide binding [IEA]
    nucleic acid binding [IEA]
    DNA binding [IEA]
    DNA-directed DNA polymerase activity [IDA][IEA]
    nucleotidyltransferase activity [IEA]
    metal ion binding [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRESNDTIQ SDTVRSSSKS DYFRIQLNNQ DYYMSKPTFL DPSHGESLPL NQFSQVPNIR  60
   61 VFGALPTGHQ VLCHVHGILP YMFIKYDGQI TDTSTLRHQR CAQVHKTLEV KIRASFKRKK 120
  121 DDKHDLAGDK LGNLNFVADV SVVKGIPFYG YHVGWNLFYK ISLLNPSCLS RISELIRDGK 180
  181 IFGKKFEIYE SHIPYLLQWT ADFNLFGCSW INVDRCYFRS PVLNSILDID KLTINDDLQL 240
  241 LLDRFCDFKC NVLSRRDFPR VGNGLIEIDI LPQFIKNREK LQHRDIHHDF LEKLGDISDI 300
  301 PVKPYVSSAR DMINELTMQR EELSLKEYKE PPETKRHVSG HQWQSSGEFE AFYKKAQHKT 360
  361 STFDGQIPNF ENFIDKNQKF SAINTPYEAL PQLWPRLPQI EINNNSMQDK KNDDQVNASF 420
  421 TEYEICGVDN ENEGVKGSNI KSRSYSWLPE SIASPKDSTI LLDHQTKYHN TINFSMDCAM 480
  481 TQNMASKRKL RSSVSANKTS LLSRKRKKVM AAGLRYGKRA FVYGEPPFGY QDILNKLEDE 540
  541 GFPKIDYKDP FFSNPVDLEN KPYAYAGKRF EISSTHVSTR IPVQFGGETV SVYNKPTFDM 600
  601 FSSWKYALKP PTYDAVQKWY NKVPSMGNKK TESQISMHTP HSKFLYKFAS DVSGKQKRKK 660
  661 SSVHDSLTHL TLEIHANTRS DKIPDPAIDE VSMIIWCLEE ETFPLDLDIA YEGIMIVHKA 720
  721 SEDSTFPTKI QHCINEIPVM FYESEFEMFE ALTDLVLLLD PDILSGFEIH NFSWGYIIER 780
  781 CQKIHQFDIV RELARVKCQI KTKLSDTWGY AHSSGIMITG RHMINIWRAL RSDVNLTQYT 840
  841 IESAAFNILH KRLPHFSFES LTNMWNAKKS TTELKTVLNY WLSRAQINIQ LLRKQDYIAR 900
  901 NIEQARLIGI DFHSVYYRGS QFKVESFLIR ICKSESFILL SPGKKDVRKQ KALECVPLVM 960
  961 EPESAFYKSP LIVLDFQSLY PSIMIGYNYC YSTMIGRVRE INLTENNLGV SKFSLPRNIL1020
 1021 ALLKNDVTIA PNGVVYAKTS VRKSTLSKML TDILDVRVMI KKTMNEIGDD NTTLKRLLNN1080
 1081 KQLALKLLAN VTYGYTSASF SGRMPCSDLA DSIVQTGRET LEKAIDIIEK DETWNAKVVY1140
 1141 GDTDSLFVYL PGKTAIEAFS IGHAMAERVT QNNPKPIFLK FEKVYHPSIL ISKKRYVGFS1200
 1201 YESPSQTLPI FDAKGIETVR RDGIPAQQKI IEKCIRLLFQ TKDLSKIKKY LQNEFFKIQI1260
 1261 GKVSAQDFCF AKEVKLGAYK SEKTAPAGAV VVKRRINEDH RAEPQYKERI PYLVVKGKQG1320
 1321 QLLRERCVSP EEFLEGENLE LDSEYYINKI LIPPLDRLFN LIGINVGNWA QEIVKSKRAS1380
 1381 TTTTKVENIT RVGTSATCCN CGEELTKICS LQLCDDCLEK RSTTTLSFLI KKLKRQKEYQ1440
 1441 TLKTVCRTCS YRYTSDAGIE NDHIASKCNS YDCPVFYSRV KAERYLRDNQ SVQREEALIS1500
 1501 LNDW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) REV3 REV7
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Qiu et al. (2008) DPB3 POL3 POL31 POL32 REV3 REV7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..496] MSA 1.135927 View MSA. No confident structure predictions are available.
    2 View Details [497..561]
    [649..941]    		 PSI-BLAST 1346.9897 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    3 View Details [562..648]
    [942..956]
    [978..1117]    		 PSI-BLAST 1346.9897 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    4 View Details [957..977]
    [1118..1214]    		 PSI-BLAST 1346.9897 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    5 View Details [1215..1394] PSI-BLAST 1346.9897 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    6 View Details [1395..1504] MSA 1.096987 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA polymerase activity
    		•  6.51831885728039 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  6.42945369067649 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  3.42625326049348 bayes_pls_golite062009
  • exonuclease activity
    		•  2.42385802668375 bayes_pls_golite062009
  • nuclease activity
    		•  2.3585392577109 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.87077985717699 bayes_pls_golite062009
  • hydrolase activity
    		•  1.69425891399878 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.57163645477983 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.56072850970382 bayes_pls_golite062009
  • transferase activity
    		•  1.50643818103939 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.40357236263993 bayes_pls_golite062009
  • catalytic activity
    		•  1.16880796007849 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.960049819952372 bayes_pls_golite062009
  • endonuclease activity
    		•  0.534786841661065 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.465219885210723 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.458511384089789 bayes_pls_golite062009
  • binding
    		•  0.398039259461279 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.302353039191978 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.267413339207743 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.139161264902915 bayes_pls_golite062009
    2
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  10.1611665880073 bayes_pls_golite062009
  • DNA polymerase activity
    		•  10.1200278407684 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  7.01618726201671 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.79232184185512 bayes_pls_golite062009
  • transferase activity
    		•  4.02382113115178 bayes_pls_golite062009
  • exonuclease activity
    		•  1.42205333874102 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.41033617404868 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • endonuclease activity
    		•  0.935348031740788 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.85118236015516 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.85118236015516 bayes_pls_golite062009
  • binding
    		•  0.808919229163124 bayes_pls_golite062009
  • DNA binding
    		•  0.70170581479383 bayes_pls_golite062009
  • DNA primase activity
    		•  0.63285588131467 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.629777822022422 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.39441061793492 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.14466215642144 bayes_pls_golite062009
  • protein binding
    		•  0.101829155879905 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.0700154911930899 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.0662718964590603 bayes_pls_golite062009
  • nuclease activity
    		•  0.0574785418962505 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  0.874307362804644 bayes_pls_golite062009
  • catalytic activity
    		•  0.223774911842048 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle