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Protein Overview: POL31

General Information:
Name(s) found: POL31 / YJR006W [SGD]
Description(s) found:
Found 28 descriptions.
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  • DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 487 amino acids

    Gene Ontology:
    Cellular Component: delta DNA polymerase complex [TASLink to PubMed article]
    Biological Process: mutagenesis [TASLink to PubMed article]
    lagging strand elongation [TASLink to PubMed article]
    base-excision repair [TASLink to PubMed article]
    leading strand elongation [TASLink to PubMed article]
    nucleotide-excision repair [TASLink to PubMed article]
    mismatch repair [TASLink to PubMed article]
    postreplication repair [TASLink to PubMed article]
    Molecular Function: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDALLTKFNE DRSLQDENLS QPRTRVRIVD DNLYNKSNPF QLCYKKRDYG SQYYHIYQYR  60
   61 LKTFRERVLK ECDKRWDAGF TLNGQLVLKK DKVLDIQGNQ PCWCVGSIYC EMKYKPNVLD 120
  121 EVINDTYGAP DLTKSYTDKE GGSDEIMLED ESGRVLLVGD FIRSTPFITG VVVGILGMEA 180
  181 EAGTFQVLDI CYPTPLPQNP FPAPIATCPT RGKIALVSGL NLNNTSPDRL LRLEILREFL 240
  241 MGRINNKIDD ISLIGRLLIC GNSVDFDIKS VNKDELMISL TEFSKFLHNI LPSISVDIMP 300
  301 GTNDPSDKSL PQQPFHKSLF DKSLESYFNG SNKEILNLVT NPYEFSYNGV DVLAVSGKNI 360
  361 NDICKYVIPS NDNGESENKV EEGESNDFKD DIEHRLDLME CTMKWQNIAP TAPDTLWCYP 420
  421 YTDKDPFVLD KWPHVYIVAN QPYFGTRVVE IGGKNIKIIS VPEFSSTGMI ILLDLETLEA 480
  481 ETVKIDI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) POL3 POL31 POL32
    View Details (MIPS) Mewes HW, et al. (2004) CDC45 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32
    View Details Krogan NJ, et al. (2006) POL3 POL30 POL31 POL32
    View Details Gavin AC, et al. (2006) POL3 POL31
    View Details Qiu et al. (2008) CDC45 CDC9 DPB11 DPB2 DPB3 DPB4 ELG1 HCS1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL1 POL12 POL2 POL3 POL30 POL31 POL32 PRI1 PRI2 RAD18 RAD30 REV3 REV7 RFC1 RFC2 RFC3 RFC4 RFC5 RRM3 SLD2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data POL31 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] deduced N/A No confident structure predictions are available.
    2 View Details [142..487] MSA 12.042994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  2.89784024382425 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.54644459918406 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.75775204356118 bayes_pls_golite062009
  • transferase activity
    		•  1.71554219929081 bayes_pls_golite062009
  • binding
    		•  1.30309680165893 bayes_pls_golite062009
  • catalytic activity
    		•  1.30037658165549 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.17916462117542 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.950264524479969 bayes_pls_golite062009
  • phosphatase activity
    		•  0.829761417192212 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.768201004870964 bayes_pls_golite062009
  • structural molecule activity
    		•  0.211411396269789 bayes_pls_golite062009
  • protein binding
    		•  0.20380491058914 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle