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Protein Overview: CDC45

General Information:
Name(s) found: CDC45 / YLR103C [SGD]
Description(s) found:
Found 26 descriptions.
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  • DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 650 amino acids

    Gene Ontology:
    Cellular Component: replication fork [IDALink to PubMed article]
    pre-replicative complex [IDALink to PubMed article]
    Biological Process: DNA replication initiation [TASLink to PubMed article]
    DNA strand elongation involved in DNA replication [TASLink to PubMed article]
    pre-replicative complex assembly [IPILink to PubMed article]
    Molecular Function: DNA binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYYGISQFSE AYNKILRNSS SHSSCQLVIF VSCLNIDALC ATKMLSLLFK KQLVQSQIVP  60
   61 IFGYSELRRH YSQLDDNINS LLLVGFGGVI DLEAFLEIDP QEYVIDTDEK SGEQSFRRDI 120
  121 YVLDAHRPWN LDNIFGSQII QCFDDGTVDD TLGEQKEAYY KLLELDEESG DDELSGDEND 180
  181 NNGGDDEATD ADEVTDEDEE DEDETISNKR GNSSIGPNDL SKRKQRKKQI HEYEGVLEEY 240
  241 YSQGTTVVNS ISAQIYSLLS AIGETNLSNL WLNILGTTSL DIAYAQVYNR LYPLLQDEVK 300
  301 RLTPSSRNSV KTPDTLTLNI QPDYYLFLLR HSSLYDSFYY SNYVNAKLSL WNENGKKRLH 360
  361 KMFARMGIPL STAQETWLYM DHSIKRELGI IFDKNLDRYG LQDIIRDGFV RTLGYRGSIS 420
  421 ASEFVEALTA LLEVGNSTDK DSVKINNDNN DDTDGEEEED NSAQKLTNLR KRWVSNFWLS 480
  481 WDALDDRKVE LLNRGIQLAQ DLQRAIFNTG VAILEKKLIK HLRIYRLCVL QDGPDLDLYR 540
  541 NPLTLLRLGN WLIECCAESE DKQLLPMVLA SIDENTDTYL VAGLTPRYPR GLDTIHTKKP 600
  601 ILNNFSMAFQ QITAETDAKV RIDNFESSII EIRREDLSPF LEKLTLSGLL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC45 CDC6 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32 SLD3
    View Details Gavin AC, et al. (2002) CDC45 ERG26 GLT1 HAT1 HSP42 LYS12 MCM2 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPD3 RPN9 SIN3 TFP1
    View Details Qiu et al. (2008) CDC45 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL30 POL31 POL32 RFC1 RFC2 RFC4 SLD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CDC45 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..650] Pfam 1000.0 CDC45-like protein No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle