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Protein Overview: ERG26

General Information:
Name(s) found: ERG26 / YGL001C [SGD]
Description(s) found:
Found 32 descriptions.
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  • C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 349 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: ergosterol biosynthetic process [IDALink to PubMed article]
    Molecular Function: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKIDSVLII GGSGFLGLHL IQQFFDINPK PDIHIFDVRD LPEKLSKQFT FNVDDIKFHK  60
   61 GDLTSPDDME NAINESKANV VVHCASPMHG QNPDIYDIVN VKGTRNVIDM CKKCGVNILV 120
  121 YTSSAGVIFN GQDVHNADET WPIPEVPMDA YNETKAIAED MVLKANDPSS DFYTVALRPA 180
  181 GIFGPGDRQL VPGLRQVAKL GQSKFQIGDN NNLFDWTYAG NVADAHVLAA QKLLDPKTRT 240
  241 AVSGETFFIT NDTPTYFWAL ARTVWKADGH IDKHVIVLKR PVAICAGYLS EWVSKMLGKE 300
  301 PGLTPFRVKI VCAYRYHNIA KAKKLLGYTP RVGIEEGINK TLAWMDEGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) ERG26 MCM7
    View Details Gavin AC, et al. (2002) CDC45 ERG26 GLT1 HAT1 HSP42 LYS12 MCM2 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPD3 RPN9 SIN3 TFP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ERG26 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..349] PSI-BLAST 159.533179 Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • steroid dehydrogenase activity
    		•  3.70115036051018 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  3.56748749904419 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  3.08644105481774 bayes_pls_golite062009
  • UDP-glucose 4-epimerase activity
    		•  2.13934644118967 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  1.80383455383329 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • receptor activity
    		•  1.59521607141455 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.57495858691649 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • ethanol binding
    		•  1.43137718523288 bayes_pls_golite062009
  • retinol binding
    		•  1.36627553306209 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.28375985874563 bayes_pls_golite062009
  • signal transducer activity
    		•  1.28375985874563 bayes_pls_golite062009
  • C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
    		•  1.03845584151228 bayes_pls_golite062009
  • DNA binding
    		•  0.925435782369235 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.830735196151903 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.805690663404413 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  0.74738022559788 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.714637370305282 bayes_pls_golite062009
  • retinoid binding
    		•  0.67821643688355 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.648902636946461 bayes_pls_golite062009
  • 11-beta-hydroxysteroid dehydrogenase activity
    		•  0.617411823427239 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.56322670082984 bayes_pls_golite062009
  • binding
    		•  0.553666136934364 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.44922383360529 bayes_pls_golite062009
  • transcription factor activity
    		•  0.288669328257774 bayes_pls_golite062009
  • all-trans retinal binding
    		•  0.218888750914841 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.192594057004213 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.0435917990586205 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.58

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle