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Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+. Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + organic acid. Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: fatty acid synthase activity
Acc: GO:0004312
Aspect: Molecular Function
Desc: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
Synonyms:
  • acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
  • fatty-acid synthase activity
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 235 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004312 - fatty acid synthase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle