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Protein Overview: POL30

General Information:
Name(s) found: POL30 / YBR088C [SGD]
Description(s) found:
Found 43 descriptions.
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  • Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: replication fork [TASLink to PubMed article]
    PCNA complex [TASLink to PubMed article]
    nucleus [IDALink to PubMed article]
    Biological Process: mutagenesis [IGILink to PubMed article][IMPLink to PubMed article]
    lagging strand elongation [IDALink to PubMed article][IPILink to PubMed article]
    base-excision repair [TASLink to PubMed article]
    leading strand elongation [IDALink to PubMed article]
    nucleotide-excision repair [IMPLink to PubMed article]
    mismatch repair [IMPLink to PubMed article][IPILink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    postreplication repair [IMPLink to PubMed article]
    Molecular Function: DNA polymerase processivity factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEAKFEEAS LFKRIIDGFK DCVQLVNFQC KEDGIIAQAV DDSRVLLVSL EIGVEAFQEY  60
   61 RCDHPVTLGM DLTSLSKILR CGNNTDTLTL IADNTPDSII LLFEDTKKDR IAEYSLKLMD 120
  121 IDADFLKIEE LQYDSTLSLP SSEFSKIVRD LSQLSDSINI MITKETIKFV ADGDIGSGSV 180
  181 IIKPFVDMEH PETSIKLEMD QPVDLTFGAK YLLDIIKGSS LSDRVGIRLS SEAPALFQFD 240
  241 LKSGFLQFFL APKFNDEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) POL3 POL30 POL31 POL32
    View Details Ho Y, et al. (2002) CDC9 CYS4 DBP9 ECM10 FPR4 IMD4 MKK2 POL30 RAD27 RPF2 RPO31 YEN1 YOR378W
    View Details Qiu et al. (2008) CDC45 DPB11 DPB2 DPB3 DPB4 MCM2 MCM4 MCM6 MRC1 POL1 POL12 POL2 POL3 POL30 POL31 POL32 PRI1 PRI2 RAD30 RFC4 SLD2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data POL30 Sundin BA, et al. (2004)
    View Data POL30 Sundin BA, et al. (2004)
    View Data POL30 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] PSI-BLAST 1391.09691 Prolifirating cell nuclear antigen (PCNA)
    2 View Details [128..258] PSI-BLAST 1391.09691 Prolifirating cell nuclear antigen (PCNA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA polymerase processivity factor activity
    		•  9.9878881203193 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  5.01426276108174 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.9656505576274 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  3.23598180825386 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.75713709757781 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  2.48680473192192 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32553487472442 bayes_pls_golite062009
  • DNA binding
    		•  2.24518789437215 bayes_pls_golite062009
  • binding
    		•  1.88302251910664 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  1.68153838099672 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  1.6296761041903 bayes_pls_golite062009
  • MutLalpha complex binding
    		•  1.21442872292245 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.14392061238362 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.785542777582287 bayes_pls_golite062009
  • catalytic activity
    		•  0.48077242755678 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.457118392479642 bayes_pls_golite062009
  • protein binding
    		•  0.452894757163315 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.408841404605319 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.387975438046246 bayes_pls_golite062009
  • transferase activity
    		•  0.345371754708312 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle