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The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. Any process that modulates the frequency, rate or extent of mismatch repair. Any process that stops, prevents or reduces the frequency, rate or extent of mismatch repair. Any process that activates or increases the frequency, rate or extent of mismatch repair. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: mismatch repair
Acc: GO:0006298
Aspect: Biological Process
Desc: A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
Synonyms:
  • long patch mismatch repair system
  • MMR
  • MutS/MutL/MutH pathway
  • GO:0006300
  • mismatch repair, MutL-like pathway
Proteins in PDR annotated with:
   This term: 143 [Search]
   Term or descendants: 155 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006298 - mismatch repair (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle