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Protein Overview: POL12

General Information:
Name(s) found: POL12 / YBL035C [SGD]
Description(s) found:
Found 31 descriptions.
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  • B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 705 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    nucleus [IDALink to PubMed articleLink to PubMed article]
    alpha DNA polymerase:primase complex [IDALink to PubMed article]
    Biological Process: DNA replication initiation [IMPLink to PubMed article]
    lagging strand elongation [ICLink to PubMed article]
    telomere capping [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: DNA binding [IEA]
    DNA-directed DNA polymerase activity [IDA][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSIDVITH FGPDADKPEI ITALENLTKL HALSVEDLYI KWEQFSNQRR QTHTDLTSKN  60
   61 IDEFKQFLQL QMEKRANQIS SSSKVNTSTK KPVIKKSLNS SPLFGLSIPK TPTLKKRKLH 120
  121 GPFSLSDSKQ TYNVGSEAET NEKGNSSLKL EFTPGMAEDA VGDSAPLSHA KSSDAKTPGS 180
  181 STFQTPTTNT PTTSRQNVPA GEILDSLNPE NIEISSGNPN VGLLSTEEPS YNQVKVEPFY 240
  241 DAKKYKFRTM RQNLQEASDV LDDQIESFTK IIQNHYKLSP NDFADPTIQS QSEIYAVGRI 300
  301 VPDSPTYDKF LNPESLSLET SRMGGVGRRV RLDLSQVNEL SFFLGQIVAF KGKNANGDYF 360
  361 TVNSILPLPY PNSPVSTSQE LQEFQANLEG SSLKVIVTCG PYFANDNFSL ELLQEFIDSI 420
  421 NNEVKPHVLI MFGPFIDITH PLIASGKLPN FPQFKTQPKT LDELFLKLFT PILKTISPHI 480
  481 QTVLIPSTKD AISNHAAYPQ ASLIRKALQL PKRNFKCMAN PSSFQINEIY FGCSNVDTFK 540
  541 DLKEVIKGGT TSSRYRLDRV SEHILQQRRY YPIFPGSIRT RIKPKDVSTK KETNDMESKE 600
  601 EKVYEHISGA DLDVSYLGLT EFVGGFSPDI MIIPSELQHF ARVVQNVVVI NPGRFIRATG 660
  661 NRGSYAQITV QCPDLEDGKL TLVEGEEPVY LHNVWKRARV DLIAS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) POL1 POL12 PRI1 PRI2
    View Details (MIPS) Mewes HW, et al. (2004) POL1 POL12 PRI1 PRI2
    View Details Krogan NJ, et al. (2006) POL1 POL12 PRI1
    View Details Gavin AC, et al. (2006) POL1 POL12 PRI1 PRI2
    View Details Gavin AC, et al. (2002) AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MIS1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RFC1 RFC3 RFC4 RFC5 RVB2 SAM1 SEC27 TFC7 TFP1 USO1 YRA1
    View Details Qiu et al. (2008) DPB2 DPB4 HCS1 MCM6 POL1 POL12 POL2 POL3 POL30 POL31 PRI1 PRI2 RFC4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data POL12 Sundin BA, et al. (2004)
    View Data POL12 Sundin BA, et al. (2004)
    View Data POL12 Sundin BA, et al. (2004)
    View Data POL12 Sundin BA, et al. (2004)
    View Data POL12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] deduced N/A No confident structure predictions are available.
    2 View Details [199..705] MSA 3.0129 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  1.87325132707337 bayes_pls_golite062009
  • binding
    		•  1.30309680165893 bayes_pls_golite062009
  • catalytic activity
    		•  1.30037658165549 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.17916462117542 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.950264524479969 bayes_pls_golite062009
  • phosphatase activity
    		•  0.829761417192212 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.768201004870964 bayes_pls_golite062009
  • structural molecule activity
    		•  0.211411396269789 bayes_pls_golite062009
  • protein binding
    		•  0.20380491058914 bayes_pls_golite062009
  • hydrolase activity
    		•  0.070797330694107 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle