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Protein Overview: RFC5

General Information:
Name(s) found: RFC5 / YBR087W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 354 amino acids

    Gene Ontology:
    Cellular Component: DNA replication factor C complex [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: sister chromatid cohesion [IPILink to PubMed article]
    leading strand elongation [IDALink to PubMed article]
    mismatch repair [TASLink to PubMed article]
    Molecular Function: DNA clamp loader activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLWVDKYRP KSLNALSHNE ELTNFLKSLS DQPRDLPHLL LYGPNGTGKK TRCMALLESI  60
   61 FGPGVYRLKI DVRQFVTASN RKLELNVVSS PYHLEITPSD MGNNDRIVIQ ELLKEVAQME 120
  121 QVDFQDSKDG LAHRYKCVII NEANSLTKDA QAALRRTMEK YSKNIRLIMV CDSMSPIIAP 180
  181 IKSRCLLIRC PAPSDSEIST ILSDVVTNER IQLETKDILK RIAQASNGNL RVSLLMLESM 240
  241 ALNNELALKS SSPIIKPDWI IVIHKLTRKI VKERSVNSLI ECRAVLYDLL AHCIPANIIL 300
  301 KELTFSLLDV ETLNTTNKSS IIEYSSVFDE RLSLGNKAIF HLEGFIAKVM CCLD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELG1 RFC1 RFC2 RFC3 RFC4 RFC5
    View Details (MIPS) Mewes HW, et al. (2004) RFC1 RFC2 RFC3 RFC4 RFC5
    View Details Krogan NJ, et al. (2006) ELG1 RFC1 RFC2 RFC3 RFC4 RFC5
    View Details Gavin AC, et al. (2006) ELG1 RFC1 RFC3 RFC4 RFC5
    View Details Gavin AC, et al. (2002) CTF18 CTF8 DPB2 ELG1 MIS1 OLA1 POL1 POL12 POL2 PRI1 PRI2 RFC1 RFC2 RFC3 RFC4 RFC5 TOP2 USO1 VPS13 YMR181C
    View Details Ho Y, et al. (2002) AHA1 CCT3 DUN1 MAP2 NPA3 RAD24 RFC2 RFC3 RFC4 RFC5 RNQ1 RPN11 RPT3 SHM2 TCP1 TMA29 YCL042W YLR413W
    View Details Qiu et al. (2008) MCM4 POL31 RFC1 RFC2 RFC3 RFC4 RFC5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RFC5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..7]
    [194..261]    		 PSI-BLAST 313.274545 Replication factor C
    2 View Details [8..193]
    [262..354]    		 PSI-BLAST 313.274545 Replication factor C

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  6.51495346697904 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  6.40748863504898 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.51625633651862 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
    		• 1.85506769032946 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  1.69026972999845 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  1.68890613599528 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.63960194106079 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.61735400124552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.60404584546501 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.1277447806079 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.677612020025357 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  0.629563765934841 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.283577486331079 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.0320943071400439 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.0320943071400439 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  0.0136229525922795 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle