YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: RFC5
Organism: Saccharomyces cerevisiae
Length: 354 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RFC5.

Description E-value Query
Range
Subject
Range
RFC4_ARATH - Replication factor C subunit 4 OS=Arabidopsis thaliana GN=RFC4 PE=2 SV=1
5.0E-69 [2..353] [9..332]
gi|2984127, gi|1... - gi|2984127|gb|AAC07663.1| DNA polymerase III gamma subunit [Aquifex aeolicus VF5], gi|15606894|ref|N...
gi|7514776 - pir||A70460 DNA polymerase III gamma subunit - Aquifex aeolicus
9.0E-69 [3..314] [5..296]
RFC3 - replication factor C (activator 1) 3, 38kDa
gi|123994885, gi... - gi|60812373|gb|AAX36209.1| replication factor C 3 [synthetic construct], gi|123994885|gb|ABM85044.1|...
2.0E-68 [1..350] [1..340]
gi|255028847 - gi|255028847|ref|ZP_05300798.1| hypothetical protein LmonL_06056 [Listeria monocytogenes LO28]
gi|224502886 - gi|224502886|ref|ZP_03671193.1| hypothetical protein LmonFR_10254 [Listeria monocytogenes FSL R2-561...
gi|224499379 - gi|224499379|ref|ZP_03667728.1| hypothetical protein LmonF1_06652 [Listeria monocytogenes Finland 19...
gi|16804741 - gi|16804741|ref|NP_466226.1| hypothetical protein lmo2704 [Listeria monocytogenes EGD-e]
gi|133728725, gi... - gi|254827269|ref|ZP_05231956.1| hypothetical protein LmonocytogeFSL_02341 [Listeria monocytogenes FS...
gi|25288580, gi|... - pir||AG1412 DNA polymerase III (gamma and tau chains) homolog dnaX [imported] - Listeria monocytogen...
3.0E-68 [2..338] [4..320]
gi|16415387, gi|... - pir||AF1788 DNA polymerase III (gamma and tau chains) homolog dnaX [imported] - Listeria innocua (st...
gi|16801912 - gi|16801912|ref|NP_472180.1| hypothetical protein lin2852 [Listeria innocua Clip11262]
5.0E-68 [2..338] [4..320]
gi|151946482 - gi|151946482|gb|EDN64704.1| replication factor C subunit 5 [Saccharomyces cerevisiae YJM789]
RFC5_YEAST - Replication factor C subunit 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RFC5 PE=1...
RFC5 - Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase t...
gi|190408751 - gi|190408751|gb|EDV12016.1| replication factor C subunit 5 [Saccharomyces cerevisiae RM11-1a]
gi|207347704 - gi|207347704|gb|EDZ73792.1| YBR087Wp-like protein [Saccharomyces cerevisiae AWRI1631]
6.0E-68 [1..354] [1..354]
RFCS_ARCFU - Replication factor C small subunit OS=Archaeoglobus fulgidus GN=rfcS PE=1 SV=1
RFCS_ARCFU - Replication factor C small subunit OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 /...
7.0E-68 [2..347] [5..311]
gi|14601459, gi|... - gi|5105207|dbj|BAA80521.1| 346aa long hypothetical replication factor C subunit [Aeropyrum pernix K1...
RFCS_AERPE - (Q9YBS7) Replication factor C small subunit (RFC small subunit) (Clamp loader small subunit)
1.0E-67 [3..347] [29..335]
gi|90584244, gi|... - gi|90584244|ref|ZP_01239984.1| AAA ATPase, central region [Staphylococcus aureus subsp. aureus JH1],...
gi|15926155, gi|... - gi|15926155|ref|NP_373688.1| DNA polymerase III gamma and tau subunits [Staphylococcus aureus subsp....
gi|156720941, gi... - gi|156978806|ref|YP_001441065.1| DNA polymerase III gamma and tau subunits [Staphylococcus aureus su...
gi|25288574 - pir||G89813 DNA polymerase III gamma and tau subunits [imported] - Staphylococcus aureus (strain N31...
gi|14246246, gi|... - gi|15923468|ref|NP_371002.1| DNA polymerase III gamma and tau subunits [Staphylococcus aureus subsp....
gi|253315726 - gi|253315726|ref|ZP_04838939.1| DNA polymerase III gamma and tau subunits [Staphylococcus aureus sub...
gi|90429477, gi|... - gi|90586946|ref|ZP_01242630.1| AAA ATPase, central region [Staphylococcus aureus subsp. aureus JH9],...
gi|255005271 - gi|255005271|ref|ZP_05143872.2| DNA polymerase III gamma and tau subunits [Staphylococcus aureus sub...
1.0E-67 [2..346] [4..322]
gi|17232424, gi|... - gi|17232424|ref|NP_488972.1| DNA polymerase III gamma and tau subunits [Nostoc sp. PCC 7120], gi|171...
gi|25531836 - pir||AD2422 DNA polymerase III gamma and tau chains [imported] - Nostoc sp. (strain PCC 7120)
2.0E-67 [3..339] [5..323]

Back

Predicted Domain #1
Region A:
Residues: [1-7]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLWVDK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [194-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDSEISTILS DVVTNERIQL ETKDILKRIA QASNGNLRVS LLMLESMALN NELALKSSSP  60
   61 IIKPDWII

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 313.274545
Match: 1iqpA_
Description: Replication factor C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 6.51495346697904 bayes_pls_golite062009
protein-DNA loading ATPase activity 6.40748863504898 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
mismatched DNA binding 2.51625633651862 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
1.85506769032946 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
guanine/thymine mispair binding 1.69026972999845 bayes_pls_golite062009
DNA insertion or deletion binding 1.68890613599528 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
microtubule motor activity 1.1277447806079 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transcription factor activity 0.697256579145077 bayes_pls_golite062009
transcription repressor activity 0.677612020025357 bayes_pls_golite062009
single base insertion or deletion binding 0.629563765934841 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
DNA strand annealing activity 0.283577486331079 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.0320943071400439 bayes_pls_golite062009
histone acetyltransferase activity 0.0320943071400439 bayes_pls_golite062009
double-strand/single-strand DNA junction binding 0.0136229525922795 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [8-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRPKSLNALS HNEELTNFLK SLSDQPRDLP HLLLYGPNGT GKKTRCMALL ESIFGPGVYR  60
   61 LKIDVRQFVT ASNRKLELNV VSSPYHLEIT PSDMGNNDRI VIQELLKEVA QMEQVDFQDS 120
  121 KDGLAHRYKC VIINEANSLT KDAQAALRRT MEKYSKNIRL IMVCDSMSPI IAPIKSRCLL 180
  181 IRCPAP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [262-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIHKLTRKIV KERSVNSLIE CRAVLYDLLA HCIPANIILK ELTFSLLDVE TLNTTNKSSI  60
   61 IEYSSVFDER LSLGNKAIFH LEGFIAKVMC CLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 313.274545
Match: 1iqpA_
Description: Replication factor C
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle