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Protein Overview: RAD24

General Information:
Name(s) found: RAD24 / YER173W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 659 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    DNA replication factor C complex [TASLink to PubMed article]
    Biological Process: DNA damage checkpoint [IMPLink to PubMed article]
    reciprocal meiotic recombination [IMPLink to PubMed article]
    nucleotide-excision repair [IMPLink to PubMed article]
    Molecular Function: DNA clamp loader activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSTNLNKRP LLQYSLSSLG SQITKWSSSR PTSPVRKARS TENDFLSKQD TSSILPSIND  60
   61 DGGEQWYEKF KPNCLEQVAI HKRKLKDVQE ALDAMFLPNA KHRILLLSGP SGCSKSTVIK 120
  121 ELSKILVPKY RQNSNGTSFR STPNEHKVTE FRGDCIVNDL PQMESFSEFL KGARYLVMSN 180
  181 LSLILIEDLP NVFHIDTRRR FQQLILQWLY SSEPLLPPLV ICITECEIPE NDNNYRKFGI 240
  241 DYTFSAETIM NKEILMHPRL KRIKFNPINS TLLKKHLKFI CVQNMKMLKE KNKWNKRQEV 300
  301 IDYIAQETGD IRSAITTLQF WATSSGSLPI STRESTISYF HAIGKVIHGS HSTNNDNEMI 360
  361 NNLFENSNNL LSKEDFKLGI LENYNTFNKG EFSISDASSI VDCLSECDNM NGLPESNEYG 420
  421 LREVRKTFRN ISKQGHNHGT VYFPREWKVR KLQNSFKVQA EDWLNVSLYK YNAVHSFRNI 480
  481 TLEFGYYAPL IRKCQSYKKK YILYYLKNLP SGSSGPKQTM DKFSDIMKVE NGIDVVDRIG 540
  541 GPIEALSVED GLAPLMDNDS NNCDHLEDQK KERDRRLRML IDQYERNVMM ANDDLEDEET 600
  601 SFNDDPIVDS DSDNSNNIGN ETFGRSDEDE SLCEILSQRQ PRKAPVISES LSDSDLEIL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AHA1 CCT3 DUN1 NPA3 RAD24 RFC2 RFC3 RFC5 RPT3 TCP1 YLR413W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RAD24 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69]
    [268..419]    		 PSI-BLAST 56.0 gamma subunit; gamma subunit of DNA polymerase III, N-domain
    2 View Details [70..267] PSI-BLAST 56.0 gamma subunit; gamma subunit of DNA polymerase III, N-domain
    3 View Details [420..659] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle