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Protein Overview: SHM2

General Information:
Name(s) found: SHM2 / YLR058C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    Biological Process: one-carbon metabolic process [TASLink to PubMed article]
    Molecular Function: glycine hydroxymethyltransferase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYTLSDAHH KLITSHLVDT DPEVDSIIKD EIERQKHSID LIASENFTST SVFDALGTPL  60
   61 SNKYSEGYPG ARYYGGNEHI DRMEILCQQR ALKAFHVTPD KWGVNVQTLS GSPANLQVYQ 120
  121 AIMKPHERLM GLYLPDGGHL SHGYATENRK ISAVSTYFES FPYRVNPETG IIDYDTLEKN 180
  181 AILYRPKVLV AGTSAYCRLI DYKRMREIAD KCGAYLMVDM AHISGLIAAG VIPSPFEYAD 240
  241 IVTTTTHKSL RGPRGAMIFF RRGVRSINPK TGKEVLYDLE NPINFSVFPG HQGGPHNHTI 300
  301 AALATALKQA ATPEFKEYQT QVLKNAKALE SEFKNLGYRL VSNGTDSHMV LVSLREKGVD 360
  361 GARVEYICEK INIALNKNSI PGDKSALVPG GVRIGAPAMT TRGMGEEDFH RIVQYINKAV 420
  421 EFAQQVQQSL PKDACRLKDF KAKVDEGSDV LNTWKKEIYD WAGEYPLAV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SHM2 YEL047C
    View Details Gavin AC, et al. (2002) GCN20 GFA1 SHM2
    View Details Ho Y, et al. (2002) ADK1 CLU1 COP1 GPH1 NAN1 PRP11 REX2 RFC3 RFC4 RFC5 RPN11 RPT3 SEC27 SHM2 SSK2 TFP1 THI22 TIF4631 TMA29 UBP15 UTP13 YCL042W YGR250C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 sample: hx1 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx2 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SHM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..46]
    [320..469]    		 PSI-BLAST 1689.0 Serine hydroxymethyltransferase
    2 View Details [47..319] PSI-BLAST 1689.0 Serine hydroxymethyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  3.2128372762799 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  3.2128372762799 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  2.47911083054773 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  2.1692959843619 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67701710033155 bayes_pls_golite062009
  • DNA binding
    		•  1.4774443071095 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39741122443159 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15775909410582 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.14675852378654 bayes_pls_golite062009
  • binding
    		•  1.09053123792737 bayes_pls_golite062009
  • structural molecule activity
    		•  0.754675308623467 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.681623261233707 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • protein binding
    		•  0.613130945854863 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.60304280865376 bayes_pls_golite062009
  • L-allo-threonine aldolase activity
    		•  0.500744432308415 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle