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Protein Overview: CCR4

General Information:
Name(s) found: CCR4 / YAL021C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 837 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Cdc73/Paf1 complex [IPILink to PubMed article]
    CCR4-NOT core complex [IPILink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    traversing start control point of mitotic cell cycle [IMPLink to PubMed article]
    nuclear-transcribed mRNA poly(A) tail shortening [IDALink to PubMed article][IMPLink to PubMed article]
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: 3'-5'-exoribonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDPSLLGYP NVGPQQQQQQ QQQQHAGLLG KGTPNALQQQ LHMNQLTGIP PPGLMNNSDV  60
   61 HTSSNNNSRQ LLDQLANGNA NMLNMNMDNN NNNNNNNNNN NNNGGGSGVM MNASTAAVNS 120
  121 IGMVPTVGTP VNINVNASNP LLHPHLDDPS LLNNPIWKLQ LHLAAVSAQS LGQPNIYARQ 180
  181 NAMKKYLATQ QAQQAQQQAQ QQAQQQVPGP FGPGPQAAPP ALQPTDFQQS HIAEASKSLV 240
  241 DCTKQALMEM ADTLTDSKTA KKQQPTGDST PSGTATNSAV STPLTPKIEL FANGKDEANQ 300
  301 ALLQHKKLSQ YSIDEDDDIE NRMVMPKDSK YDDQLWHALD LSNLQIFNIS ANIFKYDFLT 360
  361 RLYLNGNSLT ELPAEIKNLS NLRVLDLSHN RLTSLPAELG SCFQLKYFYF FDNMVTTLPW 420
  421 EFGNLCNLQF LGVEGNPLEK QFLKILTEKS VTGLIFYLRD NRPEIPLPHE RRFIEINTDG 480
  481 EPQREYDSLQ QSTEHLATDL AKRTFTVLSY NTLCQHYATP KMYRYTPSWA LSWDYRRNKL 540
  541 KEQILSYDSD LLCLQEVESK TFEEYWVPLL DKHGYTGIFH AKARAKTMHS KDSKKVDGCC 600
  601 IFFKRDQFKL ITKDAMDFSG AWMKHKKFQR TEDYLNRAMN KDNVALFLKL QHIPSGDTIW 660
  661 AVTTHLHWDP KFNDVKTFQV GVLLDHLETL LKEETSHNFR QDIKKFPVLI CGDFNSYINS 720
  721 AVYELINTGR VQIHQEGNGR DFGYMSEKNF SHNLALKSSY NCIGELPFTN FTPSFTDVID 780
  781 YIWFSTHALR VRGLLGEVDP EYVSKFIGFP NDKFPSDHIP LLARFEFMKT NTGSKKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAF130 CAF40 CCR4 CDC39 POP2
    View Details (MIPS) Mewes HW, et al. (2004) CAF16 CAF4 CCR4 CDC36 CDC39 DBF2 DHH1 IBA57 MOB1 MOT2 NOT3 NOT5 POP2
    View Details Krogan NJ, et al. (2006) CAF40 CCR4 CDC39 POP2
    View Details Gavin AC, et al. (2006) CAF40 CCR4 CDC39 POP2
    View Details Gavin AC, et al. (2002) AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TFC7 TFP1 YRA1
    View Details Ho Y, et al. (2002) CCR4 CDC36 CDC39 CYS4 PIL1 POP2 RNQ1 RVB1 STI1 UBR1
    View Details Qiu et al. (2008) CAF16 CAF4 CAF40 CCR4 CDC36 CDC39 DBF2 DHH1 IBA57 MOB1 MOT2 NOT3 NOT5 POP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CCR4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..397] PSI-BLAST 16.221849 Leucine rich effector protein YopM
    2 View Details [398..458] PSI-BLAST 13.69897 No description for 1k14A_ was found.
    3 View Details [459..837] ORFEUS 14.32 DNA repair endonuclease Hap1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  3.03637986118891 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.85165370336889 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.64138912616286 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.38142407142222 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.36300991054709 bayes_pls_golite062009
  • DNA binding
    		•  2.34848945028683 bayes_pls_golite062009
  • exonuclease activity
    		•  2.30441725834613 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.03997717198568 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.84704109624149 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  1.84015252069596 bayes_pls_golite062009
  • binding
    		•  1.77207262408714 bayes_pls_golite062009
  • catalytic activity
    		•  1.63030570728465 bayes_pls_golite062009
  • nuclease activity
    		•  1.43406183661088 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.3192080792879 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14505069034044 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.01237142327007 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.921398762372674 bayes_pls_golite062009
  • transcription activator activity
    		•  0.794530147502372 bayes_pls_golite062009
  • transcription factor binding
    		•  0.676190329566283 bayes_pls_golite062009
  • protein binding
    		•  0.477100720412367 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.456888438009074 bayes_pls_golite062009
  • phosphatase activity
    		•  0.36890149558152 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.323823757876148 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.299808718537723 bayes_pls_golite062009
  • endonuclease activity
    		•  0.122198690326292 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle