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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: Cdc73/Paf1 complex
Acc: GO:0016593
Aspect: Cellular Component
Desc: A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.
Synonyms:
  • Paf1 complex
  • Paf1p complex
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016593 - Cdc73/Paf1 complex (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle