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View Structure Prediction Details

Protein: POL12
Organism: Saccharomyces cerevisiae
Length: 705 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POL12.

Description E-value Query
Range
Subject
Range
POL12 - B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during...
DPOA2_YEAST - DNA polymerase alpha subunit B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL12 PE=...
0.0 [1..705] [1..705]
gi|32404572, gi|... - gi|32404572|ref|XP_322899.1| hypothetical protein [Neurospora crassa], gi|28922868|gb|EAA32088.1| hy...
gi|85102431 - gi|85102431|ref|XP_961324.1| hypothetical protein [Neurospora crassa OR74A]
0.0 [18..702] [22..664]
spb70 - DNA polymerase alpha B-subunit
DPOA2_SCHPO - DNA polymerase alpha subunit B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pol12 PE=1 ...
0.0 [16..703] [6..572]
gi|7301561, gi|4... - gi|74868122|sp|Q9VB62.1|DPOA2_DROME RecName: Full=DNA polymerase subunit alpha B; AltName: Full=DNA ...
0.0 [113..672] [125..633]
DPOA2_MOUSE - DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2 PE=1 SV=2
0.0 [128..678] [90..585]
DPOA2_RAT - DNA polymerase alpha subunit B OS=Rattus norvegicus GN=Pola2 PE=1 SV=2
0.0 [144..677] [1..479]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [114..672] [126..633]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSIDVITH FGPDADKPEI ITALENLTKL HALSVEDLYI KWEQFSNQRR QTHTDLTSKN  60
   61 IDEFKQFLQL QMEKRANQIS SSSKVNTSTK KPVIKKSLNS SPLFGLSIPK TPTLKKRKLH 120
  121 GPFSLSDSKQ TYNVGSEAET NEKGNSSLKL EFTPGMAEDA VGDSAPLSHA KSSDAKTPGS 180
  181 STFQTPTTNT PTTSRQNV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [199-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAGEILDSLN PENIEISSGN PNVGLLSTEE PSYNQVKVEP FYDAKKYKFR TMRQNLQEAS  60
   61 DVLDDQIESF TKIIQNHYKL SPNDFADPTI QSQSEIYAVG RIVPDSPTYD KFLNPESLSL 120
  121 ETSRMGGVGR RVRLDLSQVN ELSFFLGQIV AFKGKNANGD YFTVNSILPL PYPNSPVSTS 180
  181 QELQEFQANL EGSSLKVIVT CGPYFANDNF SLELLQEFID SINNEVKPHV LIMFGPFIDI 240
  241 THPLIASGKL PNFPQFKTQP KTLDELFLKL FTPILKTISP HIQTVLIPST KDAISNHAAY 300
  301 PQASLIRKAL QLPKRNFKCM ANPSSFQINE IYFGCSNVDT FKDLKEVIKG GTTSSRYRLD 360
  361 RVSEHILQQR RYYPIFPGSI RTRIKPKDVS TKKETNDMES KEEKVYEHIS GADLDVSYLG 420
  421 LTEFVGGFSP DIMIIPSELQ HFARVVQNVV VINPGRFIRA TGNRGSYAQI TVQCPDLEDG 480
  481 KLTLVEGEEP VYLHNVWKRA RVDLIAS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 1.87325132707337 bayes_pls_golite062009
binding 1.30309680165893 bayes_pls_golite062009
catalytic activity 1.30037658165549 bayes_pls_golite062009
protein serine/threonine phosphatase activity 1.17916462117542 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.950264524479969 bayes_pls_golite062009
phosphatase activity 0.829761417192212 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.768201004870964 bayes_pls_golite062009
structural molecule activity 0.211411396269789 bayes_pls_golite062009
protein binding 0.20380491058914 bayes_pls_golite062009
hydrolase activity 0.070797330694107 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle