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Protein Overview: HCS1

General Information:
Name(s) found: HCS1 / YKL017C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 683 amino acids

    Gene Ontology:
    Cellular Component: alpha DNA polymerase:primase complex [IDALink to PubMed article]
    Biological Process: lagging strand elongation [ICLink to PubMed article]
    Molecular Function: ATP-dependent 5'-3' DNA helicase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKELASKFL SSIKHEREQD IQTTSRLLTT LSIQQLVQNG LAINNIHLEN IRSGLIGKLY  60
   61 MELGPNLAVN DKIQRGDIKV GDIVLVRPAK TKVNTKTKPK VKKVSEDSNG EQAECSGVVY 120
  121 KMSDTQITIA LEESQDVIAT TFYSYSKLYI LKTTNVVTYN RMESTMRKLS EISSPIQDKI 180
  181 IQYLVNERPF IPNTNSFQNI KSFLNPNLND SQKTAINFAI NNDLTIIHGP PGTGKTFTLI 240
  241 ELIQQLLIKN PEERILICGP SNISVDTILE RLTPLVPNNL LLRIGHPARL LDSNKRHSLD 300
  301 ILSKKNTIVK DISQEIDKLI QENKKLKNYK QRKENWNEIK LLRKDLKKRE FKTIKDLIIQ 360
  361 SRIVVTTLHG SSSRELCSLY RDDPNFQLFD TLIIDEVSQA MEPQCWIPLI AHQNQFHKLV 420
  421 LAGDNKQLPP TIKTEDDKNV IHNLETTLFD RIIKIFPKRD MVKFLNVQYR MNQKIMEFPS 480
  481 HSMYNGKLLA DATVANRLLI DLPTVDATPS EDDDDTKIPL IWYDTQGDEF QETADEATIL 540
  541 GSKYNEGEIA IVKEHIENLR SFNVPENSIG VISPYNAQVS HLKKLIHDEL KLTDIEISTV 600
  601 DGFQGREKDV IILSLVRSNE KFEVGFLKEE RRLNVAMTRP RRQLVVVGNI EVLQRCGNKY 660
  661 LKSWSEWCEE NADVRYPNID DYL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) DPB2 HCS1 MCM3 MCM4 MCM6 MCM7 POL12 POL2 POL3 POL31 POL32 PRI1 PRI2 RRM3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HCS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] MSA 1.212988 View MSA. No confident structure predictions are available.
    2 View Details [187..683] PSI-BLAST 70.154902 DEXX box DNA helicase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle