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Protein Overview: NGG1

General Information:
Name(s) found: NGG1 / YDR176W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 702 amino acids

    Gene Ontology:
    Cellular Component: SLIK (SAGA-like) complex [IPILink to PubMed article]
    Ada2/Gcn5/Ada3 transcription activator complex [IPILink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: chromatin modification [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    histone acetylation [TASLink to PubMed article]
    Molecular Function: transcription cofactor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRHGRRGKL PKGEKLPKKE GGDNTPSKLL SSMLKTLDLT FERDIGMLNG KSVRSIPNKK  60
   61 TLLELQSQLD SLNEILGTIA RGDQETIEAL RKIRDSKNEK QANDEKQETS NADGQHESST 120
  121 ATEETNIIDK GVQSPPKPPP SNEISGTIEN DVESIKQAAD NMAKEEINED KDLQVHRDQP 180
  181 REKRPFDSET ENRATENENT QRPDNKKQKI DVDKMENDPT VKNPKSEFVV SQTLPRAAAA 240
  241 LGLFNEEGLE STGEDFLKKK YNVASYPTND LKDLLPGELP DMDFSHPKPT NQIQFNTFLA 300
  301 FVENFFKDLS DDNLKFLKMK YIIPDSLQFD KTYDPEVNPF IIPKLGPLYT DVWFKDENDK 360
  361 NSAYKKPSPY SNDASTILPK KSANELDDNA LESGSISCGP LLSRLLSAVL KDDNDKSELQ 420
  421 SSKIIRDGGL PRTGGEDDIQ SFRNNNNDTV DMTLSQENGP SVQTPDNDID EEASFQAKLA 480
  481 ENKGSNGGTT STLPQQIGWI TNGINLDYPT FEERLKRELK YVGIYMNLPK DENNPNSDDP 540
  541 DWVTGREDDE ISAELRELQG TLKQVTKKNQ KRKAQLIPLV ERQLAWQEYS SILEDLDKQI 600
  601 DQAYVKRIRV PKKRKKHHTA ASNNVNTGTT SQIAQQKAAN SSLKSLLDKR QRWINKIGPL 660
  661 FDKPEIMKRI PNESVFKDMD QEEDEDEADV FAQNTNKDVE LN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TRA1 UBP8
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Gavin AC, et al. (2006) ADA2 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
    View Details Qiu et al. (2008) ADA2 AHC1 CHD1 GCN5 HFI1 MED1 MED2 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF11 TAF12 TAF14 TAF3 TAF5 TAF6 TAF9 TFB5 TRA1 UBP8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NGG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..702] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle