YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SIN4

General Information:
Name(s) found: SIN4 / YNL236W [SGD]
Description(s) found:
Found 31 descriptions.
SHOW ALL
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 974 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    mediator complex [IDA]
    Biological Process: transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: RNA polymerase II transcription mediator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLGEHLMSW SKTGIIAYSD SQSSNANICL TFLESINGIN WRFHTPQKYV LHPQLHEVQY  60
   61 QESSSTLSTH STTTSVNGST TAGVGSTPNF GGNSNKSPPQ FFYNISSIHW NNWFSLPGDM 120
  121 LAVCDELGNM TMLITGQRPD RATTYEKLTM VFQDNVYKIY NHVMPLKPVD KLKPMNIERK 180
  181 QTRKEYNTSI LEFRWLTSSK SVIVSQFCAF DSSSNTYRSR AQQVPPYGVY HPPFIKYACL 240
  241 AIRKNGQIDF WYQFSNSKDH KKITLQLLDT SNQRFKDLQW LEFARITPMN DDQCMLITTY 300
  301 SKLSKNISFY KLHVNWNLNA TKPNVLNDPS LKIQFILSTT LDPTDDEGHV LKLENLHVVS 360
  361 KSSIEKDPSP EILVLYNVCD TSKSLVKRYR LAPTQLSAEY LVILKPDLNI DRNNSTNQIF 420
  421 QSRRYNLRRH SDIVLDKKVT LITSEMFDAF VSFYFEDGTI ESYNQNDWKL ETERLISQSQ 480
  481 LGKFKNIIAS PLSAGFNYGK LPLPPSVEWM KVSPSMCGVI VKQYNKKWPQ FYAAVQKNYA 540
  541 DPEKDSINAT ALAFGYVKSL HKQISAEDLT IAAKTHILRI SFLDRKRAKE FITTLLKSLY 600
  601 SFFNISPDAP KEIMDKIITS RPLQKIMLLQ LELGSCFSQE NIEEMARVIL YLKNVLFAFN 660
  661 GVARNFHFAI EQISNNSNQQ QNPKLFQTIF SKQDLIHSLI PVAKWFVKFI TYLTQEILIL 720
  721 INDPTNKEYT LVHGIFGAKM SRTLILSILN EIKKVTQIVA KFPETSYPIL NESSTFLKLV 780
  781 LSESPVDFEK FETFLVDVNN KFIALCEQQP SQEREFSLLV KAEIPPEYAK VGDFLLQYAN 840
  841 NAVISHANAA AVYFADTSGL KISNSEFFNP EIFHLLQPLE EGLIIDTDKL PIKNRTSKSF 900
  901 SKLLYDDVTC DKLSVSEISD GKLKRCSRCG SVTRAGNIIS SDKTIVPTSI QTKRWPTMYT 960
  961 RLCICSGMLF EMDG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 CSE2 GAL11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2 SSN3 TAF6 YAP1
    View Details (MIPS) Mewes HW, et al. (2004) CSE2 DMC1 GAL11 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 TAF14
    View Details Krogan NJ, et al. (2006) CSE2 DSS1 GAL11 GPT2 IRC11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SOH1 SRB2 SRB4 SRB5 SRB6 SRB7 SSN3 SSN8 THI72
    View Details Gavin AC, et al. (2006) CSE2 GAL11 MED1 MED11 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2
    View Details Gavin AC, et al. (2002) ADA2 ADH1 ATG26 BEM2 BUD3 CLU1 COG3 COP1 CSE2 CYR1 ENO2 FAB1 FBA1 FUN19 GAL11 GCN5 HEM13 HRR25 IMG1 IMG2 IML1 KAP114 KAP123 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MES1 MHR1 MLP1 MNN4 MOT1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MYO1 NGG1 NOP1 NUG1 NUT1 NUT2 PFK2 PGD1 PGK1 PRP43 PSK1 PTC1 PUF6 RET2 RGR1 ROM2 ROX3 RPB2 RPG1 RPN9 RPO21 RPT5 RTC6 RVB2 SEC1 SEC26 SEC27 SGF29 SGF73 SIN3 SIN4 SNF2 SPT15 SPT20 SPT7 SPT8 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 SWI3 SYP1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TIF1, TIF2 UTP20 VAS1 VPS1 YDR115W YIL077C YML6
    View Details Qiu et al. (2008) ADA2 CSE2 GAL11 GCN5 HFI1 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SOH1 SPT20 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SSN2 TAF10 TAF12 TAF14 TAF3 TAF5 TAF9 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIN4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..457] deduced N/A No confident structure predictions are available.
    2 View Details [458..641]
    [689..773]    		 ORFEUS 7.83 Hemolysin E (HlyE, ClyA, SheA)
    3 View Details [642..688] ORFEUS 7.83 Hemolysin E (HlyE, ClyA, SheA)
    4 View Details [774..974] deduced N/A No confident structure predictions are available.
    5 View Details [691..807] deduced N/A No confident structure predictions are available.
    6 View Details [808..974] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle