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Protein Overview: SEC26

General Information:
Name(s) found: SEC26 / YDR238C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 973 amino acids

    Gene Ontology:
    Cellular Component: coated vesicle [ISSLink to PubMed article]
    COPI vesicle coat [IGILink to PubMed article][ISSLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLSSQPAY TLVFDPSPSM ETYSSTDFQK ALEKGSDEQK IDTMKSILVT MLEGNPMPEL  60
   61 LMHIIRFVMP SKNKELKKLL YFYWEIVPKL AEDGKLRHEM ILVCNAIQHD LQHPNEYIRG 120
  121 NTLRFLTKLR EAELLEQMVP SVLACLEYRH AYVRKYAILA VFSIFKVSEH LLPDAKEIIN 180
  181 SFIVAETDPI CKRNAFIGLA ELDRENALHY LENNIADIEN LDPLLQAVFV QFIRQDANRT 240
  241 PALKAQYIEL LMELLSTTTS DEVIFETALA LTVLSANPNV LVPAVNKLID LAVKVSDNNI 300
  301 KLIVLDRIQD INANNVGALE ELTLDILRVL NAEDLDVRSK ALDISMDLAT SRNAEDVVQL 360
  361 LKKELQTTVN NPDQDKAMQY RQLLIKTIRT VAVNFVEMAA SVVSLLLDFI GDLNSVAASG 420
  421 IIAFIKEVIE KYPQLRANIL ENMVQTLDKV RSAKAYRGAL WIMGEYAEGE SEIQHCWKHI 480
  481 RNSVGEVPIL QSEIKKLTQN QEHTEENEVD ATAKPTGPVI LPDGTYATES AFDVKTSQKS 540
  541 VTDEERDSRP PIRRFVLSGD FYTAAILANT IIKLVLKFEN VSKNKTVINA LKAEALLILV 600
  601 SIVRVGQSSL VEKKIDEDSL ERVMTSISIL LDEVNPEEKK EEVKLLEVAF LDTTKSSFKR 660
  661 QIEIAKKNKH KRALKDSCKN IEPIDTPISF RQFAGVDSTN VQKDSIEEDL QLAMKGDAIH 720
  721 ATSSSSISKL KKIVPLCGFS DPVYAEACIT NNQFDVVLDV LLVNQTKETL KNLHVQFATL 780
  781 GDLKIIDTPQ KTNVIPHGFH KFTVTVKVSS ADTGVIFGNI IYDGAHGEDA RYVILNDVHV 840
  841 DIMDYIKPAT ADDEHFRTMW NAFEWENKIS VKSQLPTLHA YLRELVKGTN MGILTPSESL 900
  901 GEDDCRFLSC NLYAKSSFGE DALANLCIEK DSKTNDVIGY VRIRSKGQGL ALSLGDRVAL 960
  961 IAKKTNKLAL THV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) COP1 GLO3 RET2 RET3 SEC21 SEC26 SEC27 SEC28
    View Details (MIPS) Mewes HW, et al. (2004) ARF1 COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
    View Details Krogan NJ, et al. (2006) COP1 FCF2 FMP23 LCB5 PIP2 RET2 RET3 SCS2 SEC2 SEC21 SEC26 SEC27 SEC28
    View Details Gavin AC, et al. (2006) COP1 RET2 RET3 SEC21 SEC26 SEC27 SEC28
    View Details Gavin AC, et al. (2002) ATG26 BEM2 BUD3 COP1 CYR1 GLO3 GPT2 HRR25 ILV1 IMG1 IMG2 IML1 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NUG1 PGK1 PRP43 RET2 RET3 ROM2 RTC6 SAM1 SCJ1 SEC1 SEC21 SEC26 SEC27 SEC28 SEH1 SIN4 SNF2 SWI3 SYP1 TAF5 TOS1 UTP20 YDR115W YML6
    View Details Ho Y, et al. (2002) ADR1 ARG4 ATP3 AYR1 CAR2 CDC15 COP1 COR1 CPA2 CPR6 DBP8 ERG27 FMP40 GPT2 HEF3 KGD1 LIA1 LSM4 MAE1 OM45 OYE2 PAT1 PCT1 PDA1 PET10 PET9 PFK1 PGM2 PHO86 PIL1 PRB1 PRE10 PRO3 RET2 RNR1 RNR2 RPN1 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 THI22 TIF1, TIF2 TIF34 TIF35 TPA1 TRP3 UBP15 YDL086W YNL181W
    View Details Qiu et al. (2008) ARF1 ARF2 COP1 GLO3 RET2 RET3 SEC21 SEC26 SEC27 SEC28 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEC26 and COP1 Huh WK, et al. (2003)
    View Data SEC26 and ANP1 Huh WK, et al. (2003)
    View Data SEC26 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 266.0 Adaptin beta subunit N-terminal fragment
    2 View Details [107..211] PSI-BLAST 266.0 Adaptin beta subunit N-terminal fragment
    3 View Details [212..336] PSI-BLAST 266.0 Adaptin beta subunit N-terminal fragment
    4 View Details [337..436] PSI-BLAST 266.0 Adaptin beta subunit N-terminal fragment
    5 View Details [437..519] PSI-BLAST 266.0 Adaptin beta subunit N-terminal fragment
    6 View Details [520..615] PSI-BLAST 29.154902 beta-Catenin
    7 View Details [616..789] deduced N/A No confident structure predictions are available.
    8 View Details [790..973] MSA 1.01295 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • clathrin binding
    		•  3.32763559990416 bayes_pls_golite062009
  • binding
    		•  2.48958374349477 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • protein binding
    		•  1.75981610748679 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.4515576307774 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.661470469730249 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  0.20777471813851 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle