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View Structure Prediction Details

Protein: SEC26
Organism: Saccharomyces cerevisiae
Length: 973 amino acids
Reference: Malmstr÷m L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC26.

Description E-value Query
Range
Subject
Range
COPB_YEAST - Coatomer subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC26 PE=1 SV=2
SEC26 - Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and ma...
0.0 [1..973] [1..973]
gi|123983328, gi... - gi|123998029|gb|ABM86616.1| coatomer protein complex, subunit beta 1 [synthetic construct], gi|12398...
COPB1 - coatomer protein complex, subunit beta 1
0.0 [3..966] [2..952]
COPB_MOUSE - Coatomer subunit beta OS=Mus musculus GN=Copb1 PE=1 SV=1
0.0 [3..966] [2..952]
COPB_RAT - Coatomer subunit beta OS=Rattus norvegicus GN=Copb1 PE=1 SV=1
0.0 [3..966] [2..952]
gi|7447850, gi|5... - pir||T10678 hypothetical protein F3L17.50 - Arabidopsis thaliana, gi|7270051|emb|CAB79866.1| putati...
0.0 [4..966] [7..971]
gi|50900798, gi|... - gi|50900798|ref|XP_462832.1| putative coatmer beta subunit (beta-coat protein) (beta-COP) [Oryza sat...
0.0 [2..966] [84..1036]
betaCop-PA - The gene ├?Ž├?┬▓-coatomer protein is referred to in FlyBase by the symbol Dmel\├?Ž├?┬▓Cop ...
0.0 [5..969] [3..964]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLSSQPAY TLVFDPSPSM ETYSSTDFQK ALEKGSDEQK IDTMKSILVT MLEGNPMPEL  60
   61 LMHIIRFVMP SKNKELKKLL YFYWEIVPKL AEDGKLRHEM ILVCNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 266.0
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
clathrin binding 3.32763559990416 bayes_pls_golite062009
binding 2.48958374349477 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
protein binding 1.75981610748679 bayes_pls_golite062009
protein transmembrane transporter activity 1.4515576307774 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
nuclear localization sequence binding 0.661470469730249 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
nuclear export signal receptor activity 0.20777471813851 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [107-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQHDLQHPNE YIRGNTLRFL TKLREAELLE QMVPSVLACL EYRHAYVRKY AILAVFSIFK  60
   61 VSEHLLPDAK EIINSFIVAE TDPICKRNAF IGLAELDREN ALHYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 266.0
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [212-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENNIADIENL DPLLQAVFVQ FIRQDANRTP ALKAQYIELL MELLSTTTSD EVIFETALAL  60
   61 TVLSANPNVL VPAVNKLIDL AVKVSDNNIK LIVLDRIQDI NANNVGALEE LTLDILRVLN 120
  121 AEDLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 266.0
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [337-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRSKALDISM DLATSRNAED VVQLLKKELQ TTVNNPDQDK AMQYRQLLIK TIRTVAVNFV  60
   61 EMAASVVSLL LDFIGDLNSV AASGIIAFIK EVIEKYPQLR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 266.0
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [437-519]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANILENMVQT LDKVRSAKAY RGALWIMGEY AEGESEIQHC WKHIRNSVGE VPILQSEIKK  60
   61 LTQNQEHTEE NEVDATAKPT GPV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 266.0
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [520-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILPDGTYATE SAFDVKTSQK SVTDEERDSR PPIRRFVLSG DFYTAAILAN TIIKLVLKFE  60
   61 NVSKNKTVIN ALKAEALLIL VSIVRVGQSS LVEKKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.154902
Match: 1jpwA_
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [616-789]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDSLERVMT SISILLDEVN PEEKKEEVKL LEVAFLDTTK SSFKRQIEIA KKNKHKRALK  60
   61 DSCKNIEPID TPISFRQFAG VDSTNVQKDS IEEDLQLAMK GDAIHATSSS SISKLKKIVP 120
  121 LCGFSDPVYA EACITNNQFD VVLDVLLVNQ TKETLKNLHV QFATLGDLKI IDTP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [790-973]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKTNVIPHGF HKFTVTVKVS SADTGVIFGN IIYDGAHGED ARYVILNDVH VDIMDYIKPA  60
   61 TADDEHFRTM WNAFEWENKI SVKSQLPTLH AYLRELVKGT NMGILTPSES LGEDDCRFLS 120
  121 CNLYAKSSFG EDALANLCIE KDSKTNDVIG YVRIRSKGQG LALSLGDRVA LIAKKTNKLA 180
  181 LTHV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle