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Protein Overview: PIP2

General Information:
Name(s) found: PIP2 / YOR363C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 996 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: peroxisome organization [IMPLink to PubMed article]
    positive regulation of transcription [IMPLink to PubMed article][IPILink to PubMed article]
    fatty acid metabolic process [IMPLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article][ISSLink to PubMed article]
    transcription activator activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYFTDESSPA MNRVGKKRNR LSFVCQACRK AKTKCDQEKP RCGRCTKQNL FCIYDVARQA  60
   61 APRNPNKDAT IARLKKEIRY WRNKTVDLTQ EKKDFYTALK RPTEELAARR TCKSLQENSF 120
  121 PISLYKTHPR LIMTKVMKRE INPLSEKYLI FQDTFLKTLI ASVLLSCSRN SMIPALNADI 180
  181 SRSRTQPCVK NNVVKMREVL LKNSKYESQR KSINEFTDRL LQRKNPEEQI AVNKVISLLY 240
  241 SNRESSYLED TCPTENDYSD LLKGYINEIE KTLPPKAIIE QYLSHFFEHI FHLIPFASKE 300
  301 MLEESIHTTV QYNELGEVRL SMGTTLIRNK MENLCILLLI LRIAYISLTF IEDKIEDYSP 360
  361 YITKEMLEQY PIQSEVIFLA QQILASENWC ACANENTISC LLYIWCAFVF SPTEGDFLLE 420
  421 QPSDVIINLV ILIGTSIGLH RDPSDFPALN HPEASDKRLL NLRRIQWLSI ISMATLESSL 480
  481 KGRLLVSPLS MIDLFIDVRD PNCVEIYKKR VKKDLTGSES DEQLLEIHEI FFHRAQLALF 540
  541 LSDLNNITIS YSGSVPMDTL ETLRVKANEL LKNKFQLRSV DINIYDEEKT FQKLTFNSIL 600
  601 NSISLSGQIL GKLMMLRASI ALMLYFETLA MERSECLSFF YKYFFQCCAD TISLIRFFFL 660
  661 YFNGSYEKVL SSLVCFITTK VIQLAVPTTM FTLLVIIMRV ELAKNMLLVK CNECNARGDI 720
  721 SDLPEIKEKI KSLDTIKENF ERLLLEVYLL ASQNLRFKYF YIFKMLTLFD VFIQRLRKGQ 780
  781 LFSGLFVKVD KDLTTKKIAT MLELTLGINL DKSDHLIDRL KGKNLTVNFT LDQLYQIIKE 840
  841 FDRIKNIGVA DPQNSLNPSK PNMKDNTPTI ELLLNSSVEN ESVPPYSSSN DPTNVGNAST 900
  901 YSLAHNISNQ NNEENMPPSI GSSESNRAAP NLNFMPINNN YNNSGSNINN NDNVKLPSNF 960
  961 KNYYDPPMSS LDISMDVPDI FGSLDFFDYD LLFQND

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) OAF1 PIP2
    View Details Krogan NJ, et al. (2006) COP1 FCF2 FMP23 LCB5 PIP2 RET2 RET3 SCS2 SEC2 SEC21 SEC26 SEC27 SEC28

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run HSL7 No Comments McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PIP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 59.68867 Hap1 (Cyp1); HAP1
    2 View Details [112..250] deduced N/A No confident structure predictions are available.
    3 View Details [251..575] MSA 7.147996 View MSA. No confident structure predictions are available.
    4 View Details [576..996] deduced N/A No confident structure predictions are available.
    5 View Details [664..752] deduced N/A No confident structure predictions are available.
    6 View Details [753..996] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.86871420827942 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.03201524223606 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.86200506906385 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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