YRC Public Data Repository - Protein Structure Prediction

Protein:	TAF12
Organism:	Saccharomyces cerevisiae
Length:	539 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF12.

Description	E-value	Query Range	Subject Range
TAF12_YEAST - Transcription initiation factor TFIID subunit 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S... TAF12 - Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiat...	0.0	[1..539]	[1..539]
taf12 - transcription factor TFIID complex subunit A TAF12_SCHPO - Transcription initiation factor TFIID subunit 12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...	1.0E-94	[52..524]	[47..448]
TAF12_ARATH - Transcription initiation factor TFIID subunit 12 OS=Arabidopsis thaliana GN=TAF12 PE=1 SV=1	8.0E-61	[242..527]	[238..511]
gi\|220952430, gi... - gi\|220952430\|gb\|ACL88758.1\| Taf12-PA [synthetic construct], gi\|220942218\|gb\|ACL83652.1\| Taf12-PA [sy... Taf12-PB, Taf12-PA - The gene TBP-associated factor 12 is referred to in FlyBase by the symbol Dmel\Taf12 (CG17358, FBgn0...	4.0E-60	[336..517]	[21..189]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-59	[336..517]	[21..189]
TAF12_MOUSE - Transcription initiation factor TFIID subunit 12 OS=Mus musculus GN=Taf12 PE=1 SV=1	2.0E-53	[358..517]	[6..155]
gi\|123994127, gi... - gi\|61360319\|gb\|AAX41843.1\| TAF12 RNA polymerase II TATA box binding protein-associated factor [synth... TAF12 - TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	2.0E-53	[358..517]	[6..155]

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Predicted Domain #1

Region A:
Residues: [1-232]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNPENSGV NANNNTGTGN ADAITGAQQN MVLQPRQLQE MAAKFRTLLT EARNVGETTP  60
   61 RGKELMFQAA KIKQVYDALT LNRRRQQAAQ AYNNTSNSNS SNPASIPTEN VPNSSQQQQQ 120
  121 QQQQTRNNSN KFSNMIKQVL TPEENQEYEK LWQNFQVRHT SIKEKETYLK QNIDRLEQEI 180
  181 NKQTDEGPKQ QLQEKKIELL NDWKVLKIEY TKLFNNYQNS KKTFYVECAR HN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [233-405]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PALHKFLQES TQQQRVQQQR VQQQQQQQQQ QQQQQQQQQQ QQQQRQGQNQ RKISSSNSTE  60
   61 IPSVTGPDAL KSQQQQQNTI TATNNPRGNV NTSQTEQSKA KVTNVNATAS MLNNISSSKS 120
  121 AIFKQTEPAI PISENISTKT PAPVAYRSNR PTITGGSAMN ASALNTPATT KLP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [406-539]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYEMDTQRVM SKRKLRELVK TVGIDEGDGE TVIDGDVEEL LLDLADDFVT NVTAFSCRLA  60
   61 KHRKSDNLEA RDIQLHLERN WNIRIPGYSA DEIRSTRKWN PSQNYNQKLQ SITSDKVAAA 120
  121 KNNGNNVASL NTKK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.64
Match:	1h3oB
Description:	TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	9.25279783093877	bayes_pls_golite062009
histone acetyltransferase activity	5.97252613675094	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.97252613675094	bayes_pls_golite062009
N-acetyltransferase activity	4.49886535711761	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
N-acyltransferase activity	4.22222466548509	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
transcription initiation factor activity	3.96621818094279	bayes_pls_golite062009
acetyltransferase activity	3.91614625961398	bayes_pls_golite062009
acyltransferase activity	3.38611688546892	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.35015681315177	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.28941584139552	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.1782337747057	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.82448881874976	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
nucleotidyltransferase activity	1.10331930589736	bayes_pls_golite062009
protein binding	1.07873333188144	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
transcription repressor activity	0.72554769377984	bayes_pls_golite062009
histone binding	0.218942897869955	bayes_pls_golite062009
sequence-specific DNA binding	0.0852726470007639	bayes_pls_golite062009
transcription corepressor activity	0.0736756545988504	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: