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View Structure Prediction Details

Protein: TAF12
Organism: Saccharomyces cerevisiae
Length: 539 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF12.

Description E-value Query
Range		 Subject
Range
TAF12_YEAST - Transcription initiation factor TFIID subunit 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
TAF12 - Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiat...
 0.0 [1..539] [1..539]
taf12 - transcription factor TFIID complex subunit A
TAF12_SCHPO - Transcription initiation factor TFIID subunit 12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
 1.0E-94 [52..524] [47..448]
TAF12_ARATH - Transcription initiation factor TFIID subunit 12 OS=Arabidopsis thaliana GN=TAF12 PE=1 SV=1
 8.0E-61 [242..527] [238..511]
gi|220952430, gi... - gi|220952430|gb|ACL88758.1| Taf12-PA [synthetic construct], gi|220942218|gb|ACL83652.1| Taf12-PA [sy...
Taf12-PB, Taf12-PA - The gene TBP-associated factor 12 is referred to in FlyBase by the symbol Dmel\Taf12 (CG17358, FBgn0...
 4.0E-60 [336..517] [21..189]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-59 [336..517] [21..189]
TAF12_MOUSE - Transcription initiation factor TFIID subunit 12 OS=Mus musculus GN=Taf12 PE=1 SV=1
 2.0E-53 [358..517] [6..155]
gi|123994127, gi... - gi|61360319|gb|AAX41843.1| TAF12 RNA polymerase II TATA box binding protein-associated factor [synth...
TAF12 - TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
 2.0E-53 [358..517] [6..155]

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Predicted Domain #1
Region A:
Residues: [1-232] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNPENSGV NANNNTGTGN ADAITGAQQN MVLQPRQLQE MAAKFRTLLT EARNVGETTP  60
   61 RGKELMFQAA KIKQVYDALT LNRRRQQAAQ AYNNTSNSNS SNPASIPTEN VPNSSQQQQQ 120
  121 QQQQTRNNSN KFSNMIKQVL TPEENQEYEK LWQNFQVRHT SIKEKETYLK QNIDRLEQEI 180
  181 NKQTDEGPKQ QLQEKKIELL NDWKVLKIEY TKLFNNYQNS KKTFYVECAR HN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [233-405] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PALHKFLQES TQQQRVQQQR VQQQQQQQQQ QQQQQQQQQQ QQQQRQGQNQ RKISSSNSTE  60
   61 IPSVTGPDAL KSQQQQQNTI TATNNPRGNV NTSQTEQSKA KVTNVNATAS MLNNISSSKS 120
  121 AIFKQTEPAI PISENISTKT PAPVAYRSNR PTITGGSAMN ASALNTPATT KLP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [406-539] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYEMDTQRVM SKRKLRELVK TVGIDEGDGE TVIDGDVEEL LLDLADDFVT NVTAFSCRLA  60
   61 KHRKSDNLEA RDIQLHLERN WNIRIPGYSA DEIRSTRKWN PSQNYNQKLQ SITSDKVAAA 120
  121 KNNGNNVASL NTKK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.64
Match: 1h3oB
Description: TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 9.25279783093877 bayes_pls_golite062009
histone acetyltransferase activity 5.97252613675094 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.97252613675094 bayes_pls_golite062009
N-acetyltransferase activity 4.49886535711761 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
N-acyltransferase activity 4.22222466548509 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
transcription initiation factor activity 3.96621818094279 bayes_pls_golite062009
acetyltransferase activity 3.91614625961398 bayes_pls_golite062009
acyltransferase activity 3.38611688546892 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.35015681315177 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.1782337747057 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.82448881874976 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
nucleotidyltransferase activity 1.10331930589736 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009
transcription corepressor activity 0.0736756545988504 bayes_pls_golite062009
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Created and Maintained by: Michael Riffle