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Protein Overview: Taf12-PB, Taf12-PA

General Information:
Name(s) found: Taf12-PA / FBpp0081918 [FlyBase]
Taf12-PB / FBpp0081916 [FlyBase]
Description(s) found:
Found 46 descriptions.
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  • The gene TBP-associated factor 12 is referred to in FlyBase by the symbol Dmel\Taf12 (CG17358, FBgn0011290). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7504099..7505408. It has the cytological map location 86E15. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene TBP-associated factor 12 is referred to in FlyBase by the symbol Dmel\Taf12 (CG17358, FBgn0011290). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7504099..7505408. It has the cytological map location 86E15. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 196 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    transcription factor TFIID complex [ISS]
    Biological Process: regulation of transcription, DNA-dependent [NAS]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: transcription initiation factor activity [IEA]
    DNA binding [IEA]
    general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLFTTFDS NGVAEHHLHH NHNSTSSASG LLHDPPMASP SQHSPMTNNS NSSSQNGGPV  60
   61 SGLGTGTGPI SGGSKSSNHT SSAAGSENTP MLTKPRLTEL VREVDTTTQL DEDVEELLLQ 120
  121 IIDDFVEDTV KSTSAFAKHR KSNKIEVRDV QLHFERKYNM WIPGFGTDEL RPYKRAAVTE 180
  181 AHKQRLALIR KTIKKY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] FFAS03 1.18 Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase
    2 View Details [89..196] PSI-BLAST 33.30103 TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  9.25279783093877 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  3.96621818094279 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.10331930589736 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0792897588268993 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0736756545988504 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle